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Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

1
Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chunchon 24341, Korea
2
Institute of New Frontier Research, College of Medicine, Hallym University, Chunchon 24251, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 51; https://doi.org/10.3390/ijms20010051
Received: 27 November 2018 / Revised: 20 December 2018 / Accepted: 20 December 2018 / Published: 23 December 2018
(This article belongs to the Special Issue Histone Deacetylase Inhibitors in Health and Disease)
Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed. View Full-Text
Keywords: anti-cancer drug-resistance; histone deacetylase-3; cancer/testis antigen CAGE; epidermal growth factor receptor; micro RNAs; molecular network anti-cancer drug-resistance; histone deacetylase-3; cancer/testis antigen CAGE; epidermal growth factor receptor; micro RNAs; molecular network
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MDPI and ACS Style

Kwon, Y.; Kim, Y.; Jung, H.S.; Jeoung, D. Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance. Int. J. Mol. Sci. 2019, 20, 51. https://doi.org/10.3390/ijms20010051

AMA Style

Kwon Y, Kim Y, Jung HS, Jeoung D. Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance. International Journal of Molecular Sciences. 2019; 20(1):51. https://doi.org/10.3390/ijms20010051

Chicago/Turabian Style

Kwon, Yoojung; Kim, Youngmi; Jung, Hyun S.; Jeoung, Dooil. 2019. "Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance" Int. J. Mol. Sci. 20, no. 1: 51. https://doi.org/10.3390/ijms20010051

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