Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications
AbstractVitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display other important effects called “non-classical actions.” Among them, vitamin D regulates immune cells function and hematopoietic cells differentiation and proliferation. Based on these effects, it is currently being evaluated for the treatment of hematologic malignancies. In addition, vitamin D levels have been correlated with patients’ outcome after allogeneic stem cell transplantation, where it might regulate immune response and, accordingly, might influence the risk of graft-versus-host disease. Here, we present recent advances regarding its clinical applications both in the treatment of hematologic malignancies and in the transplant setting. View Full-Text
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Medrano, M.; Carrillo-Cruz, E.; Montero, I.; Perez-Simon, J.A. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. Int. J. Mol. Sci. 2018, 19, 2663.
Medrano M, Carrillo-Cruz E, Montero I, Perez-Simon JA. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. International Journal of Molecular Sciences. 2018; 19(9):2663.Chicago/Turabian Style
Medrano, Mayte; Carrillo-Cruz, Estrella; Montero, Isabel; Perez-Simon, Jose A. 2018. "Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications." Int. J. Mol. Sci. 19, no. 9: 2663.
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