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Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications

Department of Hematology, University Hospital Virgen del Rocio, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, 41013 Sevilla, Spain
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Int. J. Mol. Sci. 2018, 19(9), 2663; https://doi.org/10.3390/ijms19092663
Received: 6 August 2018 / Revised: 31 August 2018 / Accepted: 4 September 2018 / Published: 8 September 2018
(This article belongs to the Special Issue Vitamin D and Human Health)
Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display other important effects called “non-classical actions.” Among them, vitamin D regulates immune cells function and hematopoietic cells differentiation and proliferation. Based on these effects, it is currently being evaluated for the treatment of hematologic malignancies. In addition, vitamin D levels have been correlated with patients’ outcome after allogeneic stem cell transplantation, where it might regulate immune response and, accordingly, might influence the risk of graft-versus-host disease. Here, we present recent advances regarding its clinical applications both in the treatment of hematologic malignancies and in the transplant setting. View Full-Text
Keywords: vitamin D; haematopoiesis; leukaemia; myelodysplastic syndrome; allogeneic stem cell transplantation vitamin D; haematopoiesis; leukaemia; myelodysplastic syndrome; allogeneic stem cell transplantation
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MDPI and ACS Style

Medrano, M.; Carrillo-Cruz, E.; Montero, I.; Perez-Simon, J.A. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. Int. J. Mol. Sci. 2018, 19, 2663. https://doi.org/10.3390/ijms19092663

AMA Style

Medrano M, Carrillo-Cruz E, Montero I, Perez-Simon JA. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. International Journal of Molecular Sciences. 2018; 19(9):2663. https://doi.org/10.3390/ijms19092663

Chicago/Turabian Style

Medrano, Mayte, Estrella Carrillo-Cruz, Isabel Montero, and Jose A. Perez-Simon 2018. "Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications" International Journal of Molecular Sciences 19, no. 9: 2663. https://doi.org/10.3390/ijms19092663

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