Next Article in Journal
Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health
Previous Article in Journal
Pathophysiological Mechanisms of Chronic Venous Disease and Implications for Venoactive Drug Therapy
Article

Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16

1
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China
2
School of Nursing, Guangdong Pharmaceutical University, Guangzhou 510632, China
3
Institute of Brain Sciences, Jinan University, Guangzhou 510632, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1670; https://doi.org/10.3390/ijms19061670
Received: 13 May 2018 / Revised: 28 May 2018 / Accepted: 31 May 2018 / Published: 5 June 2018
(This article belongs to the Section Biochemistry)
Genetic studies have elucidated mechanisms that regulate aging; however, there has been little progress in identifying drugs that retard ageing. Caenorhabditis elegans is among the classical model organisms in ageing research. Methyl 3,4-dihydroxybenzoate (MDHB) can prolong the life-span of C. elegans, but the underlying molecular mechanisms are not yet fully understood. Here, we report that MDHB prolongs the life-span of C. elegans and delays age-associated declines of physiological processes. Besides, MDHB can lengthen the life-span of eat-2 (ad1113) mutations, revealing that MDHB does not work via caloric restriction (CR). Surprisingly, the life-span–extending activity of MDHB is completely abolished in daf-2 (e1370) mutations, which suggests that daf-2 is crucial for a MDHB-induced pro-longevity effect in C. elegans. Moreover, MDHB enhances the nuclear localization of daf-16/FoxO, and then modulates the expressions of genes that positively correlate with defenses against stress and longevity in C. elegans. Therefore, our results indicate that MDHB at least partially acts as a modulator of the daf-2/daf-16 pathway to extend the lifespan of C. elegans, and MDHB might be a promising therapeutic agent for age-related diseases. View Full-Text
Keywords: Methyl 3,4-dihydroxybenzoate; ageing; Caenorhabditis elegans; daf-2; daf-16/FoxO; oxidative stress Methyl 3,4-dihydroxybenzoate; ageing; Caenorhabditis elegans; daf-2; daf-16/FoxO; oxidative stress
Show Figures

Figure 1

MDPI and ACS Style

Mi, X.-N.; Wang, L.-F.; Hu, Y.; Pan, J.-P.; Xin, Y.-R.; Wang, J.-H.; Geng, H.-J.; Hu, S.-H.; Gao, Q.; Luo, H.-M. Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16. Int. J. Mol. Sci. 2018, 19, 1670. https://doi.org/10.3390/ijms19061670

AMA Style

Mi X-N, Wang L-F, Hu Y, Pan J-P, Xin Y-R, Wang J-H, Geng H-J, Hu S-H, Gao Q, Luo H-M. Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16. International Journal of Molecular Sciences. 2018; 19(6):1670. https://doi.org/10.3390/ijms19061670

Chicago/Turabian Style

Mi, Xiang-Nan, Li-Fang Wang, Yang Hu, Jun-Ping Pan, Yi-Rong Xin, Jia-Hui Wang, Hai-Ju Geng, Song-Hui Hu, Qin Gao, and Huan-Min Luo. 2018. "Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16" International Journal of Molecular Sciences 19, no. 6: 1670. https://doi.org/10.3390/ijms19061670

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop