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Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health

1
Department of Oncology, University of Torino, Via Santena 5 bis, 10126 Torino, Italy
2
Department of Chirurgia Generale e Specialistiche, Banca della Cute, AOU Città della Salute e della Scienza Torino, Via Zuretti 29, 10126 Torino, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(6), 1672; https://doi.org/10.3390/ijms19061672
Received: 8 May 2018 / Revised: 3 June 2018 / Accepted: 3 June 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Vitamin D and Human Health)
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Abstract

Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Recently, the mitochondrial effects of vitamin D have been characterized in many cell types. In this article, we investigated the importance of VDR not only in mitochondrial activity and integrity but also in cell health. The silencing of the receptor in different healthy, non-transformed, and cancer cells initially decreased cell growth and modulated the cell cycle. We demonstrated that, in silenced cells, the increased respiratory activity was associated with elevated reactive oxygen species (ROS) production. In the long run, the absence of the receptor caused impairment of mitochondrial integrity and, finally, cell death. Our data reveal that VDR plays a central role in protecting cells from excessive respiration and production of ROS that leads to cell damage. Because we confirmed our observations in different models of both normal and cancer cells, we conclude that VDR is essential for the health of human tissues. View Full-Text
Keywords: vitamin D receptor; silencing; mitochondria; reactive oxygen species; respiratory chain; cytochrome C; cell proliferation; cell death vitamin D receptor; silencing; mitochondria; reactive oxygen species; respiratory chain; cytochrome C; cell proliferation; cell death
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ricca, C.; Aillon, A.; Bergandi, L.; Alotto, D.; Castagnoli, C.; Silvagno, F. Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health. Int. J. Mol. Sci. 2018, 19, 1672.

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