Next Article in Journal
Annexins in Glaucoma
Next Article in Special Issue
Noncoding RNA:RNA Regulatory Networks in Cancer
Previous Article in Journal
Identification, Expression Analysis of the Hsf Family, and Characterization of Class A4 in Sedum Alfredii Hance under Cadmium Stress
Previous Article in Special Issue
The Double Face of Exosome-Carried MicroRNAs in Cancer Immunomodulation
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(4), 1217; https://doi.org/10.3390/ijms19041217

The Role of miRNAs in Virus-Mediated Oncogenesis

Department of Genetics and Microbiology, Faculty of Science, Charles University, Průmyslová 595, Vestec, CZ-25250, 128 44 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 27 February 2018 / Revised: 12 April 2018 / Accepted: 13 April 2018 / Published: 17 April 2018
(This article belongs to the Special Issue The Role of MicroRNAs in Human Diseases)
Full-Text   |   PDF [1848 KB, uploaded 3 May 2018]   |  

Abstract

To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), human herpesvirus 8 (HHV-8) or polyomaviruses, and transregulating retroviruses such as HIV or HTLV-1. Most of these viruses express short noncoding RNAs called miRNAs to regulate their own gene expression or to influence host gene expression and thus contribute to the carcinogenic processes. In this review, we will focus on oncogenic viruses and summarize the role of both types of miRNAs, viral as well as host’s, in the oncogenesis. View Full-Text
Keywords: microRNA; virus-mediated oncogenesis; viral miRNA; EBV; HHV-8; HBV; HPV; MCPyV; HCV; retroviruses microRNA; virus-mediated oncogenesis; viral miRNA; EBV; HHV-8; HBV; HPV; MCPyV; HCV; retroviruses
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Vojtechova, Z.; Tachezy, R. The Role of miRNAs in Virus-Mediated Oncogenesis. Int. J. Mol. Sci. 2018, 19, 1217.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top