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The Role of miRNAs in Virus-Mediated Oncogenesis

Department of Genetics and Microbiology, Faculty of Science, Charles University, Průmyslová 595, Vestec, CZ-25250, 128 44 Prague, Czech Republic
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 1217;
Received: 27 February 2018 / Revised: 12 April 2018 / Accepted: 13 April 2018 / Published: 17 April 2018
(This article belongs to the Special Issue The Role of MicroRNAs in Human Diseases)
To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), human herpesvirus 8 (HHV-8) or polyomaviruses, and transregulating retroviruses such as HIV or HTLV-1. Most of these viruses express short noncoding RNAs called miRNAs to regulate their own gene expression or to influence host gene expression and thus contribute to the carcinogenic processes. In this review, we will focus on oncogenic viruses and summarize the role of both types of miRNAs, viral as well as host’s, in the oncogenesis. View Full-Text
Keywords: microRNA; virus-mediated oncogenesis; viral miRNA; EBV; HHV-8; HBV; HPV; MCPyV; HCV; retroviruses microRNA; virus-mediated oncogenesis; viral miRNA; EBV; HHV-8; HBV; HPV; MCPyV; HCV; retroviruses
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MDPI and ACS Style

Vojtechova, Z.; Tachezy, R. The Role of miRNAs in Virus-Mediated Oncogenesis. Int. J. Mol. Sci. 2018, 19, 1217.

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