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Int. J. Mol. Sci. 2018, 19(2), 473;

miRNA as a New Regulatory Mechanism of Estrogen Vascular Action

Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain
INCLIVA Biomedical Research Institute, 46010 Valencia, Spain
Author to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 31 January 2018 / Accepted: 1 February 2018 / Published: 6 February 2018
(This article belongs to the Special Issue Molecular Pathways of Estrogen Receptor Action)
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The beneficial effects of estrogen on the cardiovascular system have been reported extensively. In fact, the incidence of cardiovascular diseases in women is lower than in age-matched men during their fertile stage of life, a benefit that disappears after menopause. These sex-related differences point to sexual hormones, mainly estrogen, as possible cardiovascular protective factors. The regulation of vascular function by estrogen is mainly related to the maintenance of normal endothelial function and is mediated by both direct and indirect gene transcription through the activity of specific estrogen receptors. Some of these mechanisms are known, but many remain to be elucidated. In recent years, microRNAs have been established as non-coding RNAs that regulate the expression of a high percentage of protein-coding genes in mammals and are related to the correct function of human physiology. Moreover, within the cardiovascular system, miRNAs have been related to physiological and pathological conditions. In this review, we address what is known about the role of estrogen-regulated miRNAs and their emerging involvement in vascular biology. View Full-Text
Keywords: miRNA; estradiol; estrogen receptors; epigenetic regulation; endothelial cells miRNA; estradiol; estrogen receptors; epigenetic regulation; endothelial cells

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pérez-Cremades, D.; Mompeón, A.; Vidal-Gómez, X.; Hermenegildo, C.; Novella, S. miRNA as a New Regulatory Mechanism of Estrogen Vascular Action. Int. J. Mol. Sci. 2018, 19, 473.

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