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LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer

Department of Pathology, Guangdong Medical University, Dongguan 523808, China
Department of Radiotherapy, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(2), 472;
Received: 17 January 2018 / Revised: 29 January 2018 / Accepted: 2 February 2018 / Published: 6 February 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
PDF [3876 KB, uploaded 7 February 2018]


As the most common cause of cancer death in women, the pathogenesis of breast cancer still remains unclear. Here, we reported a long non-coding RNA (lncRNA), HOTTIP (HOXA transcript at the distal tip), that may play an important role in the pathogenesis of breast cancer. Using gain-and-loss-of experiments in vitro and in vivo, we observed the marked upregulation of HOTTIP/HOXA11 in the breast cancer cell line, MCF-7, and the downregulation of HOTTIP or HOXA11, which might inhibit cell proliferation and migration but promote cell apoptosis in breast cancer MCF-7 cells. In addition, by further rescue experiments with HOXA11 overexpression, we uncovered a novel potential regulatory mechanism between HOTTIP and one of its physical HOXA clusters, HOXA11. Hence, HOTTIP may mediate, at least partly, HOXA11 expression involved in cell growth, migration, and apoptosis of breast cancer MCF-7 cells. View Full-Text
Keywords: HOTTIP; breast cancer; growth; migration; apoptosis HOTTIP; breast cancer; growth; migration; apoptosis

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Sun, Y.; Zeng, C.; Gan, S.; Li, H.; Cheng, Y.; Chen, D.; Li, R.; Zhu, W. LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer. Int. J. Mol. Sci. 2018, 19, 472.

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