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Int. J. Mol. Sci. 2017, 18(2), 397;

Calcium Signaling in Interstitial Cells: Focus on Telocytes

Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie 8, Verona 37134, Italy
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, Bucharest 050095, Romania
Research Beyond Limits, Dimitrie Cantemir 15, Bucharest 040234, Romania
Engineering Faculty, Constantin Brancusi University, Calea Eroilor 30, Targu Jiu 210135, Romania
Department of Life and Environmental Physics, Horia Hulubei National Institute of Physics and Nuclear Engineering, Reactorului 30, P.O. Box MG-6, Magurele 077125, Romania
Division of Cell Biology and Histology, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania
Victor Babes National Institute of Pathology, Bucharest 050096, Romania
Author to whom correspondence should be addressed.
Academic Editor: ChulHee Kang
Received: 4 October 2016 / Revised: 4 January 2017 / Accepted: 25 January 2017 / Published: 13 February 2017
(This article belongs to the Special Issue Calcium Regulation and Sensing)
Full-Text   |   PDF [3194 KB, uploaded 13 February 2017]   |  


In this review, we describe the current knowledge on calcium signaling pathways in interstitial cells with a special focus on interstitial cells of Cajal (ICCs), interstitial Cajal-like cells (ICLCs), and telocytes. In detail, we present the generation of Ca2+ oscillations, the inositol triphosphate (IP3)/Ca2+ signaling pathway and modulation exerted by cytokines and vasoactive agents on calcium signaling in interstitial cells. We discuss the physiology and alterations of calcium signaling in interstitial cells, and in particular in telocytes. We describe the physiological contribution of calcium signaling in interstitial cells to the pacemaking activity (e.g., intestinal, urinary, uterine or vascular pacemaking activity) and to the reproductive function. We also present the pathological contribution of calcium signaling in interstitial cells to the aortic valve calcification or intestinal inflammation. Moreover, we summarize the current knowledge of the role played by calcium signaling in telocytes in the uterine, cardiac and urinary physiology, and also in various pathologies, including immune response, uterine and cardiac pathologies. View Full-Text
Keywords: interstitial cells; telocytes; calcium signaling; Ca2+ oscillations; pacemaker activity interstitial cells; telocytes; calcium signaling; Ca2+ oscillations; pacemaker activity

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Radu, B.M.; Banciu, A.; Banciu, D.D.; Radu, M.; Cretoiu, D.; Cretoiu, S.M. Calcium Signaling in Interstitial Cells: Focus on Telocytes. Int. J. Mol. Sci. 2017, 18, 397.

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