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Int. J. Mol. Sci. 2017, 18(12), 2638; https://doi.org/10.3390/ijms18122638

In Vitro Effect of 3D Plates Used for Surgical Treatment of Condylar Fractures on Prostaglandin E2 (PGE2) and Thromboxane B2 (TXB2) Concentration in THP-1 Macrophages

1
Department of Maxillofacial Surgery, Hospital of the Ministry of Interior, Kielce, Wojska Polskiego 51, 25-375 Kielce, Poland
2
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powst. Wlkp. 72; 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 29 November 2017 / Accepted: 2 December 2017 / Published: 8 December 2017
(This article belongs to the Section Biochemistry)
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Abstract

Recent studies have shown promising results concerning the effectiveness of 3D plates in terms of stabilization of condylar fractures. Despite the use of new techniques and new materials, we can still observe certain side effects, including the immune reaction of the body, which may lead to the excessive inflammation. The aim of this paper was to determine how the production of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) in THP-1 monocytes/macrophages is influenced by the titanium 3D plates and dedicated screws. The experiments were conducted on THP-1 monocytic cell line and macrophages derived from a THP-1cells. The concentrations of PGE2 and TXB2 released were measured by using immunoassay kit. Verification of plate-induced activation of THP-1 monocytes and macrophages and initiation of inflammatory reaction was conducted by flow cytometry. Despite some differences in the content of the implant devices our results showed that these plates did not statistically significantly increase the production of these prostanoids. Osteosynthesis of condylar fractures using 3D titanium mini-plates seems to be a good alternative to traditional plates due to their lack of stimulating the cyclooxygenase-dependent production of prostanoids; limiting the development of inflammatory reactions. View Full-Text
Keywords: 3D titanium mini-plates; condylar fracture; prostaglandin E2 (PGE2); thromboxane B2 (TXB2), macrophages; inflammation 3D titanium mini-plates; condylar fracture; prostaglandin E2 (PGE2); thromboxane B2 (TXB2), macrophages; inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sikora, M.; Goschorska, M.; Baranowska-Bosiacka, I.; Chlubek, D. In Vitro Effect of 3D Plates Used for Surgical Treatment of Condylar Fractures on Prostaglandin E2 (PGE2) and Thromboxane B2 (TXB2) Concentration in THP-1 Macrophages. Int. J. Mol. Sci. 2017, 18, 2638.

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