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Int. J. Mol. Sci. 2017, 18(10), 2145; https://doi.org/10.3390/ijms18102145

A Functional Interplay between IGF-1 and Adiponectin

1
Dipartimento di Scienze Motorie e del Benessere, Università degli Studi di Napoli “Parthenope”, via Medina 40, 80133 Napoli, Italy
2
IRCCS SDN, via E. Gianturco 113, 80142 Napoli, Italy
3
CEINGE-Biotecnologie Avanzate S.c.a r.l., Via G. Salvatore 486, 80145 Napoli, Italy
4
Dipartimento di Medicina e di Scienze della Salute “Vincenzo Tiberio” Università degli Studi del Molise, Campobasso, Italy
5
Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Università della Campania “Luigi Vanvitelli”, Via G. Vivaldi 42, 81100 Caserta, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 31 July 2017 / Revised: 2 October 2017 / Accepted: 9 October 2017 / Published: 14 October 2017
(This article belongs to the Special Issue IGFs in Health and Disease)
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Abstract

A functional relationship is suggested between two well-known protein hormones, insulin-like growth factor 1 (IGF-1) and adiponectin. In the last two decades in fact, different experimental evidence has indicated a non-random link between them. Here, we describe briefly the IGF-1 and adiponectin systems, and we then focus on their putative interplay in relation to several pathological conditions, including obesity, diabetes, insulin resistance, cardiovascular disease, and cancer. Although the existing studies are hardly comparable, they definitely indicate a functional connection between these two protein hormones. In conclusion, the current knowledge strongly encourages further research into the common, as well as novel, mechanisms through which IGF-1 and adiponectin exert their concerted action. View Full-Text
Keywords: insulin-like growth factor-1 (IGF-1); growth hormone (GH); adiponectin; obesity; diabetes; insulin resistance; heart failure; cardiovascular disease; cancer insulin-like growth factor-1 (IGF-1); growth hormone (GH); adiponectin; obesity; diabetes; insulin resistance; heart failure; cardiovascular disease; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Orrù, S.; Nigro, E.; Mandola, A.; Alfieri, A.; Buono, P.; Daniele, A.; Mancini, A.; Imperlini, E. A Functional Interplay between IGF-1 and Adiponectin. Int. J. Mol. Sci. 2017, 18, 2145.

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