Mechanisms Underlying the Immune Response Generated by an Oral Vibrio cholerae Vaccine
AbstractMechanistic details underlying the resulting protective immune response generated by mucosal vaccines remain largely unknown. We investigated the involvement of Toll-like receptor signaling in the induction of humoral immune responses following oral immunization with Dukoral, comparing wild type mice with TLR-2-, TLR-4-, MyD88- and Trif-deficient mice. Although all groups generated similar levels of IgG antibodies, the proliferation of CD4+ T-cells in response to V. cholerae was shown to be mediated via MyD88/TLR signaling, and independently of Trif signaling. The results demonstrate differential requirements for generation of immune responses. These results also suggest that TLR pathways may be modulators of the quality of immune response elicited by the Dukoral vaccine. Determining the critical signaling pathways involved in the induction of immune response to this vaccine would be beneficial, and could contribute to more precisely-designed versions of other oral vaccines in the future. View Full-Text
Share & Cite This Article
Sirskyj, D.; Kumar, A.; Azizi, A. Mechanisms Underlying the Immune Response Generated by an Oral Vibrio cholerae Vaccine. Int. J. Mol. Sci. 2016, 17, 1062.
Sirskyj D, Kumar A, Azizi A. Mechanisms Underlying the Immune Response Generated by an Oral Vibrio cholerae Vaccine. International Journal of Molecular Sciences. 2016; 17(7):1062.Chicago/Turabian Style
Sirskyj, Danylo; Kumar, Ashok; Azizi, Ali. 2016. "Mechanisms Underlying the Immune Response Generated by an Oral Vibrio cholerae Vaccine." Int. J. Mol. Sci. 17, no. 7: 1062.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.