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Int. J. Mol. Sci. 2016, 17(6), 940;

Hepatitis B Virus X Protein and Hepatocarcinogenesis

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore
Department of Hepatobiliary & Pancreas Surgery, The First Hospital, Jilin University, Changchun 130021, China
Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, 169610 Singapore, Singapore
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 117456 Singapore, Singapore
Duke-NUS Graduate Medical School, 169857 Singapore, Singapore
Author to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 3 May 2016 / Revised: 18 May 2016 / Accepted: 24 May 2016 / Published: 14 June 2016
(This article belongs to the Collection Molecular Mechanisms of Human Liver Diseases)
Full-Text   |   PDF [1292 KB, uploaded 14 June 2016]   |  


Chronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic and genetic processes. This review will examine and summarize recent literature about HBx’s role in these various processes. View Full-Text
Keywords: HBx protein; hepatocarcinogenesis; hepatocellular carcinoma HBx protein; hepatocarcinogenesis; hepatocellular carcinoma

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Liu, S.; Koh, S.S.Y.; Lee, C.G.L. Hepatitis B Virus X Protein and Hepatocarcinogenesis. Int. J. Mol. Sci. 2016, 17, 940.

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