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Hypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental Relationship

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli, Italy
Department of Molecular Medicine, “Sapienza” University of Rome, 00161 Rome, Italy
Author to whom correspondence should be addressed.
Academic Editor: Amal Kaddoumi
Int. J. Mol. Sci. 2016, 17(3), 347;
Received: 21 December 2015 / Revised: 20 February 2016 / Accepted: 29 February 2016 / Published: 8 March 2016
(This article belongs to the Special Issue Amyloid-beta and Neurological Diseases)
PDF [406 KB, uploaded 8 March 2016]


Hypertension and dementia represent two major public health challenges worldwide, notably in the elderly population. Although these two conditions have classically been recognized as two distinct diseases, mounting epidemiological, clinical and experimental evidence suggest that hypertension and dementia are strictly intertwined. Here, we briefly report how hypertension profoundly affects brain homeostasis, both at the structural and functional level. Chronic high blood pressure modifies the cerebral vasculature, increasing the risk of Aβ clearance impairment. The latter, excluding genetic etiologies, is considered one of the main causes of Aβ deposition in the brain. Studies have shown that hypertension induces cerebral arterial stiffening and microvascular dysfunction, thus contributing to dementia pathophysiology. This review examines the existing and the updated literature which has attempted to explain and clarify the relationship between hypertension and dementia at the pathophysiological level. View Full-Text
Keywords: hypertension; cerebrovascular dysfunction; vascular cognitive impairment; molecular mechanisms hypertension; cerebrovascular dysfunction; vascular cognitive impairment; molecular mechanisms

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Perrotta, M.; Lembo, G.; Carnevale, D. Hypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental Relationship. Int. J. Mol. Sci. 2016, 17, 347.

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