Trianthema portulacastrum Linn. Displays Anti-Inflammatory Responses during Chemically Induced Rat Mammary Tumorigenesis through Simultaneous and Differential Regulation of NF-κB and Nrf2 Signaling Pathways
Abstract
:1. Introduction
2. Results
2.1. TPE Suppresses Elevated COX-2 Expression during DMBA-Induced Mammary Tumorigenesis
2.2. TPE Inhibits HSP90 Expression during DMBA Mammary Carcinogenesis
2.3. TPE Attenuates Activation of NF-κB during Mammary Tumorigenesis
2.4. TPE Upregulates Nrf2 Expression during Mammary Tumorigenesis Induced by DMBA
3. Discussion
4. Experimental Section
4.1. Plant Material
4.2. Chemicals and Antibodies
4.3. Experimental Design and Tissue Harvesting
4.4. Immunohistochemical Analysis
4.5. Statistical Analyses
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Mandal, A.; Bishayee, A. Trianthema portulacastrum Linn. Displays Anti-Inflammatory Responses during Chemically Induced Rat Mammary Tumorigenesis through Simultaneous and Differential Regulation of NF-κB and Nrf2 Signaling Pathways. Int. J. Mol. Sci. 2015, 16, 2426-2445. https://doi.org/10.3390/ijms16022426
Mandal A, Bishayee A. Trianthema portulacastrum Linn. Displays Anti-Inflammatory Responses during Chemically Induced Rat Mammary Tumorigenesis through Simultaneous and Differential Regulation of NF-κB and Nrf2 Signaling Pathways. International Journal of Molecular Sciences. 2015; 16(2):2426-2445. https://doi.org/10.3390/ijms16022426
Chicago/Turabian StyleMandal, Animesh, and Anupam Bishayee. 2015. "Trianthema portulacastrum Linn. Displays Anti-Inflammatory Responses during Chemically Induced Rat Mammary Tumorigenesis through Simultaneous and Differential Regulation of NF-κB and Nrf2 Signaling Pathways" International Journal of Molecular Sciences 16, no. 2: 2426-2445. https://doi.org/10.3390/ijms16022426