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Intercellular Signaling Pathway among Endothelia, Astrocytes and Neurons in Excitatory Neuronal Damage

1
Medical Research Institute, Tokyo Women's Medical University, Shinjuku, Tokyo 162-8666, Japan
2
Neural Plasticity Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(4), 8345-8357; https://doi.org/10.3390/ijms14048345
Received: 1 February 2013 / Revised: 20 March 2013 / Accepted: 3 April 2013 / Published: 16 April 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
Neurons interact closely with astrocytes via glutamate; this neuron-glia circuit may play a pivotal role in synaptic transmission. On the other hand, astrocytes contact vascular endothelial cells with their end-feet. It is becoming obvious that non-neuronal cells play a critical role in regulating the neuronal activity in the brain. We find that kainic acid (KA) administration induces the expression of microsomal prostaglandin E synthase-1 (mPGES-1) in venous endothelial cells and the prostaglandin E2 (PGE2) receptor prostaglandin E receptor (EP)-3 on astrocytes. Endothelial mPGES-1 exacerbates KA-induced neuronal damage in in vivo experiments. In in vitro experiments, mPGES-1 produces PGE2, which enhances astrocytic Ca2+ levels via the EP3 receptor and increases Ca2+-dependent glutamate release, thus aggravating neuronal injury. This novel endothelium-astrocyte-neuron signaling pathway may be crucial for driving neuronal damage after repetitive seizures and could be a new therapeutic target for epilepsy and other brain disorders. View Full-Text
Keywords: microsomal prostaglandin E synthase-1 (mPGES-1); prostaglandin E2 (PGE2); endothelial cell; EP3; kainic acid; Ca2+ levels; astrocyte; neuronal damage microsomal prostaglandin E synthase-1 (mPGES-1); prostaglandin E2 (PGE2); endothelial cell; EP3; kainic acid; Ca2+ levels; astrocyte; neuronal damage
MDPI and ACS Style

Takemiya, T.; Yamagata, K. Intercellular Signaling Pathway among Endothelia, Astrocytes and Neurons in Excitatory Neuronal Damage. Int. J. Mol. Sci. 2013, 14, 8345-8357.

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