Next Article in Journal
Applications of Circular Dichroism for Structural Analysis of Gelatin and Antimicrobial Peptides
Previous Article in Journal
Modulation Role of Abscisic Acid (ABA) on Growth, Water Relations and Glycinebetaine Metabolism in Two Maize (Zea mays L.) Cultivars under Drought Stress
Article Menu

Export Article

Open AccessReview

Tannins, Peptic Ulcers and Related Mechanisms

Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(3), 3203-3228;
Received: 29 January 2012 / Revised: 26 February 2012 / Accepted: 28 February 2012 / Published: 8 March 2012
PDF [255 KB, uploaded 19 June 2014]


This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract anti-inflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products. View Full-Text
Keywords: tannins; antiulcer activity; gastric ulcer; natural products; Helicobacter pylori tannins; antiulcer activity; gastric ulcer; natural products; Helicobacter pylori
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

De Jesus, N.Z.T.; Falcão, H.S.; Gomes, I.F.; Leite, T.J.A.; Lima, G.R.M.; Barbosa-Filho, J.M.; Tavares, J.F.; Silva, M.S.; Athayde-Filho, P.F.; Batista, L.M. Tannins, Peptic Ulcers and Related Mechanisms. Int. J. Mol. Sci. 2012, 13, 3203-3228.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top