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International Journal of Molecular Sciences, Volume 11, Issue 12

December 2010 - 39 articles

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Articles (39)

  • Article
  • Open Access
65 Citations
12,383 Views
16 Pages

Antiproliferative Effects of Cucurbitacin B in Breast Cancer Cells: Down-Regulation of the c-Myc/hTERT/Telomerase Pathway and Obstruction of the Cell Cycle

  • Suwit Duangmano,
  • Sumana Dakeng,
  • Weena Jiratchariyakul,
  • Apichart Suksamrarn,
  • Duncan R. Smith and
  • Pimpicha Patmasiriwat

22 December 2010

Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from the Thai herb Trichosanthes cucumerina L. on telomerase re...

  • Article
  • Open Access
4 Citations
10,013 Views
9 Pages

22 December 2010

We previously showed that plasminogen (Plg) isolated from the plasma of normal human subjects contains 1–2 moles of oxidized phosphatidylcholine (oxPtdPC) adducts/mole of protein. Moreover, we suggested that these species are generated at the hepatic...

  • Article
  • Open Access
36 Citations
10,728 Views
19 Pages

Screening of Molecular Virulence Markers in Staphylococcus aureus and Pseudomonas aeruginosa Strains Isolated from Clinical Infections

  • Ani-Ioana Cotar,
  • Mariana-Carmen Chifiriuc,
  • Sorin Dinu,
  • Marcela Bucur,
  • Carmen Iordache,
  • Otilia Banu,
  • Olguta Dracea,
  • Cristina Larion and
  • Veronica Lazar

21 December 2010

Staphylococcus (S.) aureus and Pseudomonas (Ps.) aeruginosa are two of the most frequently opportunistic pathogens isolated in nosocomial infections, responsible for severe infections in immunocompromised hosts. The frequent emergence of antibiotic-r...

  • Review
  • Open Access
46 Citations
12,040 Views
17 Pages

Intrinsically Disordered Proteins in a Physics-Based World

  • Timothy H. Click,
  • Debabani Ganguly and
  • Jianhan Chen

21 December 2010

Intrinsically disordered proteins (IDPs) are a newly recognized class of functional proteins that rely on a lack of stable structure for function. They are highly prevalent in biology, play fundamental roles, and are extensively involved in human dis...

  • Article
  • Open Access
37 Citations
8,929 Views
13 Pages

21 December 2010

Chronic mild stress (CMS) affects the hippocampal structure and function in the rat. S100B, a calcium-binding protein secreted by astrocytes, has been shown to be increased in serum of patients with depression and associated with good therapeutic res...

  • Article
  • Open Access
81 Citations
12,796 Views
17 Pages

20 December 2010

The interaction between cells and biopolymers is the evaluation indicator of the biocompatibility of materials. The purpose of this work was to examine the responses of retinal pigment epithelial (RPE) cells to genipin (GP) or glutaraldehyde (GTA) cr...

  • Article
  • Open Access
78 Citations
10,618 Views
11 Pages

Anti-Tumor Activity of a Novel Protein Obtained from Tartary Buckwheat

  • Xiaona Guo,
  • Kexue Zhu,
  • Hui Zhang and
  • Huiyuan Yao

17 December 2010

TBWSP31 is a novel antitumor protein that was isolated from tartary buckwheat water-soluble extracts. The objective of this paper was to investigate the anti-proliferative effects of TBWSP31 on breast cancer Bcap37cells and to explore its possible me...

  • Article
  • Open Access
26 Citations
10,170 Views
12 Pages

17 December 2010

In aerobic organisms, protection against oxidative damage involves the combined action of highly specialized antioxidant enzymes, such as copper-zinc superoxide dismutase. In this work, a cDNA clone which encodes a copper-zinc superoxide dismutase ge...

  • Article
  • Open Access
4 Citations
8,680 Views
10 Pages

17 December 2010

: Effects of Fe-chlorophyllin on the growth of wheat root were investigated in this study. We found that Fe-chlorophyllin can promote root growth. The production of nitric oxide in wheat root was detected using DAF-2DA fluorescent emission. The inten...

  • Review
  • Open Access
74 Citations
12,305 Views
22 Pages

17 December 2010

Deleted in Malignant Brain Tumors-1 protein (DMBT1), salivary agglutinin (DMBT1SAG), and lung glycoprotein-340 (DMBT1GP340) are three names for glycoproteins encoded by the same DMBT1 gene. All these proteins belong to the scavenger receptor cysteine...

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Int. J. Mol. Sci. - ISSN 1422-0067