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Molecules 2001, 6(2), 130-141;

Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme

Department of Chemistry, Macquarie University, Sydney NSW 2109, Australia
Department of Aquatic Zoology, Western Australian Museum, Perth WA 6000, Australia
Author to whom correspondence should be addressed.
Received: 4 July 2000 / Accepted: 10 January 2001 / Published: 16 January 2001
(This article belongs to the Special Issue RACI Natural Products Group Symposium)
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By specifically targeting sponges likely to contain oroidin derivatives, we have, for the first time, identified Australian sponges that contain sceptrin (2) and related compounds. Using a simple extraction technique and HPLC (with a photodiode array detector) in combination with LC-MS and MS-MS we have been able to quickly identify known compounds and flag the presence of some new compounds in the extracts. Further work will entail isolation and structure elucidation of the new compounds and collection of fresh Agelas sp.1 with the aim of isolating the enzyme that catalyses the [2 + 2] dimerisation or oroidin to sceptrin View Full-Text
Keywords: Agelas; sceptrin; sponge; [2+2] photoaddition Agelas; sceptrin; sponge; [2+2] photoaddition

Figure 1

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Hao, E.; Fromont, J.; Jardine, D.; Karuso, P. Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme. Molecules 2001, 6, 130-141.

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