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Open AccessArticle

The Impact of Composites with Silicate-Based Glasses and Gold Nanoparticles on Skin Wound Regeneration

1
Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania
2
Faculty of Physics, Babeș-Bolyai University, 400084 Cluj-Napoca, Romania
3
Interdisciplinary Research Institute on Bio-Nano-Science, Babeș-Bolyai University, 400271 Cluj-Napoca, Romania
4
Department of Applied and Environmental Chemistry, University of Szeged, 6720 Szeged, Hungary
5
Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Giuseppe Cirillo
Molecules 2021, 26(3), 620; https://doi.org/10.3390/molecules26030620
Received: 18 December 2020 / Revised: 19 January 2021 / Accepted: 19 January 2021 / Published: 25 January 2021
(This article belongs to the Special Issue Research on Nanostructured Materials)
The silver content of the skin regeneration ointments can influence its regeneration process but in the meantime, it can take the benefit of the antibacterial properties of silver by avoiding the bacterial infection of an open wound. In the current study, the skin healing and regeneration capacity of bioactive glass with spherical gold nanocages (BGAuIND) in the Vaseline ointments were evaluated in vivo comparing the bioactive glass (BG)-Vaseline and bioactive glass with spherical gold (BGAuSP)-Vaseline ointments. Spherical gold nanocages are stabilized with silver and as a consequence the BGAuIND exhibits great antibacterial activity. Histological examination of the cutaneous tissue performed on day 8 indicates a more advanced regeneration process in rats treated with BGAuSP-Vaseline. The histopathological examination also confirms the results obtained after 11 days post-intervention, when the skin is completely regenerated at rats treated with BGAuSP-Vaseline compared with the others groups where the healing was incomplete. This result is also confirmed by the macroscopic images of the evolution of wounds healing. As expected, the silver content influences the wound healing process but after two weeks, for all of the post-interventional trials from the groups of rats, the skin healing was completely. View Full-Text
Keywords: wound healing; in vivo; Vaseline; immunological assay; histopathology wound healing; in vivo; Vaseline; immunological assay; histopathology
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MDPI and ACS Style

Mârza, S.M.; Magyari, K.; Bogdan, S.; Moldovan, M.; Peștean, C.; Nagy, A.; Gal, A.F.; Tăbăran, F.; Purdoiu, R.C.; Licărete, E.; Suarasan, S.; Baia, L.; Papuc, I. The Impact of Composites with Silicate-Based Glasses and Gold Nanoparticles on Skin Wound Regeneration. Molecules 2021, 26, 620. https://doi.org/10.3390/molecules26030620

AMA Style

Mârza SM, Magyari K, Bogdan S, Moldovan M, Peștean C, Nagy A, Gal AF, Tăbăran F, Purdoiu RC, Licărete E, Suarasan S, Baia L, Papuc I. The Impact of Composites with Silicate-Based Glasses and Gold Nanoparticles on Skin Wound Regeneration. Molecules. 2021; 26(3):620. https://doi.org/10.3390/molecules26030620

Chicago/Turabian Style

Mârza, Sorin M.; Magyari, Klara; Bogdan, Sidonia; Moldovan, Mirela; Peștean, Cosmin; Nagy, Andras; Gal, Adrian F.; Tăbăran, Flaviu; Purdoiu, Robert C.; Licărete, Emilia; Suarasan, Sorina; Baia, Lucian; Papuc, Ionel. 2021. "The Impact of Composites with Silicate-Based Glasses and Gold Nanoparticles on Skin Wound Regeneration" Molecules 26, no. 3: 620. https://doi.org/10.3390/molecules26030620

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