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Article

Semi-Automated Determination of Heavy Metals in Autopsy Tissue Using Robot-Assisted Sample Preparation and ICP-MS

1
Institute of Automation, University of Rostock, 18119 Rostock, Germany
2
Department of Orthopedics, University Medical Center, 18057 Rostock, Germany
3
Institute of Legal Medicine, University Medical Center, 18055 Rostock, Germany
4
Center for Life Science Automation (Celisca), University of Rostock, 18119 Rostock, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Zikri Arslan and Tomasz Kowalkowski
Molecules 2021, 26(13), 3820; https://doi.org/10.3390/molecules26133820
Received: 19 April 2021 / Revised: 17 June 2021 / Accepted: 17 June 2021 / Published: 23 June 2021
The endoprosthetic care of hip and knee joints introduces multiple materials into the human body. Metal containing implant surfaces release degradation products such as particulate wear and corrosion debris, metal-protein complexes, free metallic ions, inorganic metal salts or oxides. Depending on the material composition of the prostheses, a systemic exposure occurs and may result in increasing metal concentrations in body fluids and tissues especially in the case of malfunctions of the arthroplasty components. High concentrations of Cr, Co, Ni, Ti and Al affect multiple organs such as thyroid, heart, lung and cranial nerves and may lead to metallosis, intoxications, poly-neuropathy, retinopathy, cardiomyopathy and the formation of localized pseudo tumors. The determination of the concentration of metals in body fluids and tissues can be used for predicting failure of hip or knee replacements to prevent subsequent severe intoxications. A semi-automated robot-assisted measurement system is presented for the determination of heavy metals in human tissue samples using inductively coupled plasma mass spectrometry (ICP-MS). The manual and automated measurement processes were similarly validated using certified reference material and the results are compared and discussed. The automation system was successfully applied in the determination of heavy metals in human tissue; the first results are presented. View Full-Text
Keywords: automated measurements; compound-oriented measurements; robot-assisted sample preparation; heavy metals; hip implant; knee implant; periprosthetic autopsy tissue; ICP-MS automated measurements; compound-oriented measurements; robot-assisted sample preparation; heavy metals; hip implant; knee implant; periprosthetic autopsy tissue; ICP-MS
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MDPI and ACS Style

Fleischer, H.; Lutter, C.; Büttner, A.; Mittelmeier, W.; Thurow, K. Semi-Automated Determination of Heavy Metals in Autopsy Tissue Using Robot-Assisted Sample Preparation and ICP-MS. Molecules 2021, 26, 3820. https://doi.org/10.3390/molecules26133820

AMA Style

Fleischer H, Lutter C, Büttner A, Mittelmeier W, Thurow K. Semi-Automated Determination of Heavy Metals in Autopsy Tissue Using Robot-Assisted Sample Preparation and ICP-MS. Molecules. 2021; 26(13):3820. https://doi.org/10.3390/molecules26133820

Chicago/Turabian Style

Fleischer, Heidi, Christoph Lutter, Andreas Büttner, Wolfram Mittelmeier, and Kerstin Thurow. 2021. "Semi-Automated Determination of Heavy Metals in Autopsy Tissue Using Robot-Assisted Sample Preparation and ICP-MS" Molecules 26, no. 13: 3820. https://doi.org/10.3390/molecules26133820

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