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Checking NEKs: Overcoming a Bottleneck in Human Diseases

1
Instituto de Biologia, Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas, Campinas, São Paulo 13083-862, Brazil
2
Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas, Campinas, São Paulo 13083-871, Brazil
3
Laboratório Multidisciplinar em Alimentos e Saúde, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, São Paulo 13484-350, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(8), 1778; https://doi.org/10.3390/molecules25081778
Received: 10 March 2020 / Revised: 2 April 2020 / Accepted: 9 April 2020 / Published: 13 April 2020
In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been linked to important human diseases, although some kinase families remain neglected in terms of research, hiding their relevance to therapeutic approaches. Here, a review regarding the NEK family is presented, shedding light on important information related to NEKs and human diseases. NEKs are a large group of homologous kinases with related functions and structures that participate in several cellular processes such as the cell cycle, cell division, cilia formation, and the DNA damage response. The review of the literature points to the pivotal participation of NEKs in important human diseases, like different types of cancer, diabetes, ciliopathies and central nervous system related and inflammatory-related diseases. The different known regulatory molecular mechanisms specific to each NEK are also presented, relating to their involvement in different diseases. In addition, important information about NEKs remains to be elucidated and is highlighted in this review, showing the need for other studies and research regarding this kinase family. Therefore, the NEK family represents an important group of kinases with potential applications in the therapy of human diseases. View Full-Text
Keywords: NEKs; cancer; disorders NEKs; cancer; disorders
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MDPI and ACS Style

Peres de Oliveira, A.; Kazuo Issayama, L.; Betim Pavan, I.C.; Riback Silva, F.; Diniz Melo-Hanchuk, T.; Moreira Simabuco, F.; Kobarg, J. Checking NEKs: Overcoming a Bottleneck in Human Diseases. Molecules 2020, 25, 1778.

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