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Natural Products as Modulators of Sirtuins

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey
Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle (Saale), Germany
Department of Chemistry, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon
Institute of Botany, Technical University of Dresden, 01217 Dresden, Germany
Author to whom correspondence should be addressed.
Academic Editor: José Rubén Tormo
Molecules 2020, 25(14), 3287;
Received: 22 January 2020 / Revised: 12 July 2020 / Accepted: 15 July 2020 / Published: 20 July 2020
(This article belongs to the Special Issue Structure–Activity Relationships (SAR) of Natural Products)
Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources there has been a decline in financial support and efforts in characterization of natural products. Advances in the design of chemical compounds and the understanding of their functions is of pharmacological importance for the biomedical field. However, natural products regained attention as sources of novel drug candidates upon recent developments and progress in technology. Natural compounds were shown to bear an inherent ability to bind to biomacromolecules and cover an unparalleled chemical space in comparison to most libraries used for high-throughput screening. Thus, natural products hold a great potential for the drug discovery of new scaffolds for therapeutic targets such as sirtuins. Sirtuins are Class III histone deacetylases that have been linked to many diseases such as Parkinson`s disease, Alzheimer’s disease, type II diabetes, and cancer linked to aging. In this review, we examine the revitalization of interest in natural products for drug discovery and discuss natural product modulators of sirtuins that could serve as a starting point for the development of isoform selective and highly potent drug-like compounds, as well as the potential application of naturally occurring sirtuin inhibitors in human health and those in clinical trials. View Full-Text
Keywords: natural products; sirtuin; drug discovery; epigenetics; structure–activity relationship natural products; sirtuin; drug discovery; epigenetics; structure–activity relationship
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MDPI and ACS Style

Karaman Mayack, B.; Sippl, W.; Ntie-Kang, F. Natural Products as Modulators of Sirtuins. Molecules 2020, 25, 3287.

AMA Style

Karaman Mayack B, Sippl W, Ntie-Kang F. Natural Products as Modulators of Sirtuins. Molecules. 2020; 25(14):3287.

Chicago/Turabian Style

Karaman Mayack, Berin, Wolfgang Sippl, and Fidele Ntie-Kang. 2020. "Natural Products as Modulators of Sirtuins" Molecules 25, no. 14: 3287.

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