Next Article in Journal
Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven Morus spp. Cultivated in Thailand
Next Article in Special Issue
Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells
Previous Article in Journal
Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling
Previous Article in Special Issue
Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?
Article

Extra Virgin Olive Oil Phenols Dilate the Rat Mesenteric Artery by Activation of BKCa2+ Channels in Smooth Muscle Cells

1
Department of Biology, Ecology & Earth Sciences, University of Calabria, 87036 Rende (CS), Italy
2
Research Centre for Olive, Citrus and Tree Fruit—Council for Agricultural Research and Economics, 87036 Rende (CS), Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Pierluigi Plastina and Roberto Fabiani
Molecules 2020, 25(11), 2601; https://doi.org/10.3390/molecules25112601
Received: 17 April 2020 / Revised: 15 May 2020 / Accepted: 29 May 2020 / Published: 3 June 2020
(This article belongs to the Special Issue Lipids in Health and Disease)
Accumulating evidence has shown the beneficial health effects of extra virgin olive oil (EVOO) consumption in reducing blood pressure and preventing the risk of developing hypertension. Some studies associate the hypotensive activity of EVOO to a minor component—the phenols. This study was designed to investigate the effects of EVOO phenols on the rat resistance mesenteric artery (MA) and to find out the possible vascular pathways involved. The experiments were carried out using a pressurized myograph, which allowed the effects of phenols on isolated MA to be tested under different conditions: (a) with endothelium removed; (b) with inhibition of nitric oxide synthase by Nω-Nitro-l-arginine methyl ester hydrochloride (l-NAME, 10−4 M) + Nω-Nitro-l-arginine (l-NNA, 10−4 M); (c) with inhibition of cyclooxygenase by indomethacin (10−5 M); (d) with inhibition of guanylate cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ,10−5 M) or adenylate cyclase by 9-(Tetrahydro-2′-furyl)adenine (SQ, 10−5 M); (e) with depolarization by high potassium chloride (40 mM); and (f) with inhibition of the large conductance Ca2+–potassium channels (BKCa2+) with paxilline (10−5 M). EVOO phenols induce vasodilation of the endothelium, mediated by a direct effect on smooth muscle cells (SMC) by activation of BKCa2+ channels, an action by which phenols can regulate the vascular tone of the resistance artery. Phenols can be regarded as bioactive molecules that may contribute to the antihypertensive effects of EVOO. View Full-Text
Keywords: extra virgin olive oil phenols; mesenteric artery; vasodilation; smooth muscle cells; BKCa2+ channels extra virgin olive oil phenols; mesenteric artery; vasodilation; smooth muscle cells; BKCa2+ channels
Show Figures

Figure 1

MDPI and ACS Style

D’Agostino, R.; Barberio, L.; Gatto, M.; Muzzalupo, I.; Mandalà, M. Extra Virgin Olive Oil Phenols Dilate the Rat Mesenteric Artery by Activation of BKCa2+ Channels in Smooth Muscle Cells. Molecules 2020, 25, 2601. https://doi.org/10.3390/molecules25112601

AMA Style

D’Agostino R, Barberio L, Gatto M, Muzzalupo I, Mandalà M. Extra Virgin Olive Oil Phenols Dilate the Rat Mesenteric Artery by Activation of BKCa2+ Channels in Smooth Muscle Cells. Molecules. 2020; 25(11):2601. https://doi.org/10.3390/molecules25112601

Chicago/Turabian Style

D’Agostino, Rossana, Laura Barberio, MariaCarmela Gatto, Innocenzo Muzzalupo, and Maurizio Mandalà. 2020. "Extra Virgin Olive Oil Phenols Dilate the Rat Mesenteric Artery by Activation of BKCa2+ Channels in Smooth Muscle Cells" Molecules 25, no. 11: 2601. https://doi.org/10.3390/molecules25112601

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop