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Open AccessArticle

Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses

by Chae Hyun Kim 1,†, Jung-Eun Kim 1,2,† and Yoon-Jae Song 1,*
1
Department of Life Science, Gachon University, Seongnam-Si, Gyeonggi-Do 13120, Korea
2
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(10), 2379; https://doi.org/10.3390/molecules25102379
Received: 16 April 2020 / Revised: 13 May 2020 / Accepted: 17 May 2020 / Published: 20 May 2020
(This article belongs to the Special Issue Antiviral Properties of Natural Products)
We previously reported that the ethyl acetate (EtOAc) fraction of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) inhibits varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) replication in vitro. PGG (1,2,3,4,6-penta-O-galloyl-ß-D-glucose) is a major chemical constituent of the EtOAc fraction of ESE that inhibits VZV but not HCMV replication. In this study, we comprehensively screened the chemical compounds identified in the EtOAc fraction of ESE for potential antiviral properties. Among the examined compounds, quercetin and isoquercitrin displayed potent antiviral activities against both VZV and HCMV with no significant cytotoxic effects. Both compounds strongly suppressed the expression of VZV and HCMV immediate–early (IE) genes. Our collective results indicated that, in addition to PGG, quercetin and isoquercitrin are bioactive compounds in the EtOAc fraction of ESE that effectively inhibit human herpesvirus replication. View Full-Text
Keywords: varicella-zoster virus; human cytomegalovirus; antiviral; quercetin; isoquercitrin varicella-zoster virus; human cytomegalovirus; antiviral; quercetin; isoquercitrin
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MDPI and ACS Style

Kim, C.H.; Kim, J.-E.; Song, Y.-J. Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses. Molecules 2020, 25, 2379.

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