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Open AccessReview

Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis

1
Graduate Institute of Cancer Biology and Drug Discovery, Collage of Medical Science and Technology, Taipei Medical University, Taipei 11024, Taiwan
2
Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11024, Taiwan
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(10), 2380; https://doi.org/10.3390/molecules25102380
Received: 5 May 2020 / Revised: 15 May 2020 / Accepted: 16 May 2020 / Published: 20 May 2020
Prostate cancer (PCa) is one of the most prevalent and malignant cancer types in men, which causes more than three-hundred thousand cancer death each year. At late stage of PCa progression, bone marrow is the most often metastatic site that constitutes almost 70% of metastatic cases of the PCa population. However, the characteristic for the osteo-philic property of PCa is still puzzling. Recent studies reported that the Wnt and Ras signaling pathways are pivotal in bone metastasis and that take parts in different cytological changes, but their crosstalk is not well studied. In this review, we focused on interactions between the Wnt and Ras signaling pathways during each stage of bone metastasis and present the fate of those interactions. This review contributes insights that can guide other researchers by unveiling more details with regard to bone metastasis and might also help in finding potential therapeutic regimens for preventing PCa bone metastasis. View Full-Text
Keywords: Wnt; Ras; prostate cancer; bone metastasis; cross reaction Wnt; Ras; prostate cancer; bone metastasis; cross reaction
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MDPI and ACS Style

Lin, S.-R.; Mokgautsi, N.; Liu, Y.-N. Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis. Molecules 2020, 25, 2380.

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