Next Article in Journal
IgGs from Human Milk Hydrolyze microRNAs
Previous Article in Journal
Foliar Application of Bio-Stimulants Enhancing the Production and the Toxicity of Origanum majorana Essential Oils Against Four Rice Seed-Borne Fungi
Open AccessArticle

Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts

1
Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh 11451, Saudi Arabia
2
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
3
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
4
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
5
Pharmacognosy Department, Faculty of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), Giza 12511, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(10), 2365; https://doi.org/10.3390/molecules25102365
Received: 6 April 2020 / Revised: 8 May 2020 / Accepted: 9 May 2020 / Published: 20 May 2020
(This article belongs to the Section Medicinal Chemistry)
A new abietane diterpene namely plectrabarbene (2), together with two known compounds: sugiol (1) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (3) have been isolated from the aerial parts of Plectranthus barbatus Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes (13) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil. View Full-Text
Keywords: Plectranthus barbatus; Labiatae; plectrabarbene; abietane diterpene; acetylcholinesterase inhibition; molecular docking Plectranthus barbatus; Labiatae; plectrabarbene; abietane diterpene; acetylcholinesterase inhibition; molecular docking
Show Figures

Figure 1

MDPI and ACS Style

Al Musayeib, N.M.; Amina, M.; Al-Hamoud, G.A.; Mohamed, G.A.; Ibrahim, S.R.; Shabana, S. Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts. Molecules 2020, 25, 2365.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop