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Open AccessArticle

Phenolic Profile, Antioxidant and Anti-Proliferative Activities of Methanolic Extracts from Asclepias linaria Cav. Leaves

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Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Michoacán, Jiquilpan 59510, Michoacán, Mexico
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CONACYT-Instituto Nacional de Pediatría, Coyoacán 04530, Ciudad de México, Mexico
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Unidad de Servicios Analíticos y Metrológicos, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A.C. (CIATEJ), Guadalajara 44270, Jalisco, Mexico
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CONACYT - Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Michoacán, Jiquilpan 59510, Michoacán, Mexico
*
Author to whom correspondence should be addressed.
Academic Editors: Monika Waksmundzka-Hajnos and Lillian Barros
Molecules 2020, 25(1), 54; https://doi.org/10.3390/molecules25010054
Received: 20 November 2019 / Revised: 17 December 2019 / Accepted: 18 December 2019 / Published: 23 December 2019
(This article belongs to the Special Issue Chromatographic Science of Natural Products)
Asclepias linaria Cav. (Apocynaceae) is a shrubby plant endemic of Mexico which has been used in traditional medicine. However, the bioactive potential of this plant remains unexplored. In this study, the phenolic composition, antioxidant, and cytotoxic activities of A. linaria leaves were determined. In order to estimate the phenolic composition of the leaves, the total phenolic, flavonoid, and condensed tannins contents were determined. Furthermore, the antioxidant activity was measured by the scavenging activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid] (ABTS•+) radicals and the total antioxidant capacity. The phenolic compounds identified in the A. linaria leaves by ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-MS) include phenolic acids, such as p-coumaric and ferulic acid, as well as flavonoids, such as rutin and quercetin. The leaves’ extracts of A. linaria showed a high scavenging activity of DPPH and ABTS•+ radicals (IC50 0.12 ± 0.001 and 0.51 ± 0.003 µg/mL, respectively), high total antioxidant capacity values (99.77 ± 4.32 mg of ascorbic acid equivalents/g of dry tissue), and had a cytotoxic effect against K562 and HL60 hematologic neoplasia cells lines, but no toxicity towards the normal mononuclear cell line was observed. These results highlight the potential of A. linaria and could be considered as a possible alternative source of anticancer compounds. View Full-Text
Keywords: scavenging activity; phenolic compounds; antioxidant activity; ultra-performance liquid chromatography (UPLC); cytotoxic activity; Asclepias linaria scavenging activity; phenolic compounds; antioxidant activity; ultra-performance liquid chromatography (UPLC); cytotoxic activity; Asclepias linaria
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MDPI and ACS Style

Sánchez-Gutiérrez, J.A.; Moreno-Lorenzana, D.; Álvarez-Bernal, D.; Rodríguez-Campos, J.; Medina-Medrano, J.R. Phenolic Profile, Antioxidant and Anti-Proliferative Activities of Methanolic Extracts from Asclepias linaria Cav. Leaves. Molecules 2020, 25, 54. https://doi.org/10.3390/molecules25010054

AMA Style

Sánchez-Gutiérrez JA, Moreno-Lorenzana D, Álvarez-Bernal D, Rodríguez-Campos J, Medina-Medrano JR. Phenolic Profile, Antioxidant and Anti-Proliferative Activities of Methanolic Extracts from Asclepias linaria Cav. Leaves. Molecules. 2020; 25(1):54. https://doi.org/10.3390/molecules25010054

Chicago/Turabian Style

Sánchez-Gutiérrez, José A.; Moreno-Lorenzana, Dafné; Álvarez-Bernal, Dioselina; Rodríguez-Campos, Jacobo; Medina-Medrano, José R. 2020. "Phenolic Profile, Antioxidant and Anti-Proliferative Activities of Methanolic Extracts from Asclepias linaria Cav. Leaves" Molecules 25, no. 1: 54. https://doi.org/10.3390/molecules25010054

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