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Open AccessArticle

Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells

1
Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
2
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama, Hiroshima 729-0292, Japan
3
School of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari, Tobetsu, Hokkaido 061-0293, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Molecules 2019, 24(7), 1366; https://doi.org/10.3390/molecules24071366
Received: 1 March 2019 / Revised: 4 April 2019 / Accepted: 5 April 2019 / Published: 7 April 2019
(This article belongs to the Section Medicinal Chemistry)
Many studies have demonstrated that oxidative stress plays an important role in several ailments including neurodegenerative diseases and cerebral ischemic injury. Previously we synthesized some carbazole compounds that have anti-oxidant ability in vitro. In this present study, we found that one of these 22 carbazole compounds, compound 13 (3-ethoxy-1-hydroxy-8- methoxy-2-methylcarbazole-5-carbaldehyde), had the ability to protect neuro2a cells from hydrogen peroxide-induced cell death. It is well known that neurite loss is one of the cardinal features of neuronal injury. Our present study revealed that compound 13 had the ability to induce neurite outgrowth through the PI3K/Akt signaling pathway in neuro2a cells. These findings suggest that compound 13 might exert a neurotrophic effect and thus be a useful therapy for the treatment of brain injury. View Full-Text
Keywords: carbazole; neuro2a cells; neurite outgrowth; neuronal death; anti-oxidant carbazole; neuro2a cells; neurite outgrowth; neuronal death; anti-oxidant
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Furukawa, Y.; Sawamoto, A.; Yamaoka, M.; Nakaya, M.; Hieda, Y.; Choshi, T.; Hatae, N.; Okuyama, S.; Nakajima, M.; Hibino, S. Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells. Molecules 2019, 24, 1366.

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