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Molecules 2019, 24(6), 1047; https://doi.org/10.3390/molecules24061047

Role of Natural Products in Modulating Histone Deacetylases in Cancer

1
Faculty of Pharmacy, University of Paris Descartes, 75006 Paris, France
2
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
3
Stem Cell and Cancer Biology Laboratory, Curtin Health Innovation Research Institute, School of Biomedical Sciences, Curtin University, Perth, WA 6009, Australia
4
College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
5
Department of Korean Pathology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-Dong Dongdaemun-Gu, Seoul 130-701, Korea
*
Authors to whom correspondence should be addressed.
Received: 15 February 2019 / Revised: 12 March 2019 / Accepted: 13 March 2019 / Published: 16 March 2019
(This article belongs to the Special Issue Next Generation Histone Deacetylase (HDAC) Inhibitors)
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Abstract

Histone deacetylases (HDACs) are enzymes that can control transcription by modifying chromatin conformation, molecular interactions between the DNA and the proteins as well as the histone tail, through the catalysis of the acetyl functional sites removal of proteins from the lysine residues. Also, HDACs have been implicated in the post transcriptional process through the regulation of the proteins acetylation, and it has been found that HDAC inhibitors (HDACi) constitute a promising class of pharmacological drugs to treat various chronic diseases, including cancer. Indeed, it has been demonstrated that in several cancers, elevated HDAC enzyme activities may be associated with aberrant proliferation, survival and metastasis. Hence, the discovery and development of novel HDACi from natural products, which are known to affect the activation of various oncogenic molecules, has attracted significant attention over the last decade. This review will briefly emphasize the potential of natural products in modifying HDAC activity and thereby attenuating initiation, progression and promotion of tumors. View Full-Text
Keywords: HDACs; cancer; natural products; proliferation; metastasis HDACs; cancer; natural products; proliferation; metastasis
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Merarchi, M.; Sethi, G.; Shanmugam, M.K.; Fan, L.; Arfuso, F.; Ahn, K.S. Role of Natural Products in Modulating Histone Deacetylases in Cancer. Molecules 2019, 24, 1047.

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