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Molecules 2019, 24(6), 1003; https://doi.org/10.3390/molecules24061003

Bioactive 2-(Methyldithio)Pyridine-3-Carbonitrile from Persian Shallot (Allium stipitatum Regel.) Exerts Broad-Spectrum Antimicrobial Activity

1
Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor Darul Ehsan, Malaysia
2
Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, Bandar Puncak Alam 42300, Selangor Darul Ehsan, Malaysia
3
Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Basij Square, Arak 38481-7-6941, Iran
4
School of Medicine, Taylor’s University, Lakeside Campus, No. 1, Jalan Taylor’s, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
5
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah 52571, Kingdom of Saudi Arabia
6
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126 Jalan Bukit Jalil, Kuala Lumpur 57000, Malaysia
7
R & D Microbiology, BioMerieux, 3 route de Port Michaud, 38390 La Balme-les-Grottes, France
*
Author to whom correspondence should be addressed.
Received: 16 October 2018 / Revised: 29 January 2019 / Accepted: 1 February 2019 / Published: 13 March 2019
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [1216 KB, uploaded 13 March 2019]   |  

Abstract

Antibiotic resistance is a problem that continues to challenge the healthcare sector, especially in clinically significant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Herein is described the isolation and structure elucidation of a bioactive compound from Allium stipitatum with antimicrobial activity. Crude Allium stipitatum dichloromethane extract (ASDE) was subjected to systematic purification by chromatographic procedures to afford various bioactive fractions. A fraction that exhibited anti-MRSA activity (4 µg·mL−1) was further characterized to determine the structure. The structure of the compound was elucidated as 2-(methyldithio)pyridine-3-carbonitrile (2-Medpy-3-CN). The 2-Medpy-3-CN compound, which was screened for antimicrobial activity, exhibited minimum inhibitory concentrations (MICs) in the range of 0.5 to >64 µg·mL−1 for tested bacterial species and 0.25 to 2 µg·mL−1 for Candida spp. Further studies are important to confirm the drug target and mechanism of action. View Full-Text
Keywords: Allium stipitatum; antibacterial; minimum inhibitory concentration; methicillin-resistant Staphylococcus aureus Allium stipitatum; antibacterial; minimum inhibitory concentration; methicillin-resistant Staphylococcus aureus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Karunanidhi, A.; Ghaznavi-Rad, E.; Jeevajothi Nathan, J.; Joseph, N.; Chigurupati, S.; Mohd Fauzi, F.; Pichika, M.R.; Hamat, R.A.; Lung, L.T.T.; van Belkum, A.; Neela, V. Bioactive 2-(Methyldithio)Pyridine-3-Carbonitrile from Persian Shallot (Allium stipitatum Regel.) Exerts Broad-Spectrum Antimicrobial Activity. Molecules 2019, 24, 1003.

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