An Improved Method for the Quaternization of Nicotinamide and Antifungal Activities of Its Derivatives
AbstractThe quaternization reactions of nicotinamide, with different electrophiles: methyl iodide and substituted 2-bromoacetophenones (4-Cl, 4-Br, 4-H, 4-CH3, 4-F, 4-OCH3, 4-Ph, 2-OCH3, 4-NO2) are reported. The preparations were carried out by conventional synthesis and under microwave irradiation in absolute ethanol and acetone. The synthesis performed by microwave dielectric heating significantly improved yield, up to 8 times, and shortened down the reaction time from ca. one day in conventional, to 10–20 min. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR spectroscopy, mass spectrometry and elemental analysis. The compounds have been screened for antifungal activities against Fusarium oxysporum, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum at concentrations of 10 µg/mL and 100 µg/mL. Six compounds showed the strong inhibition of mycelium growth at a concentration of 10 µg/mL. All tested compounds revealed the great inhibitory activities against S. sclerotiorum at a concentration of 100 µg/mL. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 4217 KB)
Share & Cite This Article
Siber, T.; Bušić, V.; Zobundžija, D.; Roca, S.; Vikić-Topić, D.; Vrandečić, K.; Gašo-Sokač, D. An Improved Method for the Quaternization of Nicotinamide and Antifungal Activities of Its Derivatives. Molecules 2019, 24, 1001.
Siber T, Bušić V, Zobundžija D, Roca S, Vikić-Topić D, Vrandečić K, Gašo-Sokač D. An Improved Method for the Quaternization of Nicotinamide and Antifungal Activities of Its Derivatives. Molecules. 2019; 24(6):1001.Chicago/Turabian Style
Siber, Tamara; Bušić, Valentina; Zobundžija, Dora; Roca, Sunčica; Vikić-Topić, Dražen; Vrandečić, Karolina; Gašo-Sokač, Dajana. 2019. "An Improved Method for the Quaternization of Nicotinamide and Antifungal Activities of Its Derivatives." Molecules 24, no. 6: 1001.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.