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Bioactivity-Guided Isolation and Identification of New and Immunosuppressive Monoterpenoid Indole Alkaloids from Rauvolfia yunnanensis Tsiang

by Li-Mei Li 1,2,*, Shun-Dong Shi 2, Yang Liu 2 and Qiang Zou 2
1
School of Pharmacy, Southwest University for Nationalities, Chengdu 610041, Sichuan, China
2
Research Center, Chengdu Medical College, Chengdu 610500, Sichuan, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(24), 4574; https://doi.org/10.3390/molecules24244574
Received: 21 November 2019 / Revised: 11 December 2019 / Accepted: 12 December 2019 / Published: 13 December 2019
Three new 11-hydroxyburnamine (1) and rauvoyunnanines A–B (23), and fourteen known (417) monoterpenoid indole alkaloids were isolated from the total alkaloids extract of Rauvolfia yunnanensis, which exhibited promising immunosuppressive activity on T cell proliferation in preliminary screening. Their structures were determined by analysis of high-resolution electrospray ionization mass (HRESIMS), ultraviolet (UV) and nuclear magnetic resonance (NMR) data, and by comparison with the literature. All the alkaloids were evaluated for inhibitory activity on T cell proliferation. Among them, one new compound (1) and reserpine (6) exhibited moderate immunosuppressive activity, with IC50 values of 5.9 μM and 5.0 μM, respectively. View Full-Text
Keywords: Rauvolfia yunnanensis; monoterpenoid indole alkaloid; 11-hydroxyburnamine; rauvoyunnanine A; rauvoyunnanine B; immunosuppressive activity Rauvolfia yunnanensis; monoterpenoid indole alkaloid; 11-hydroxyburnamine; rauvoyunnanine A; rauvoyunnanine B; immunosuppressive activity
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MDPI and ACS Style

Li, L.-M.; Shi, S.-D.; Liu, Y.; Zou, Q. Bioactivity-Guided Isolation and Identification of New and Immunosuppressive Monoterpenoid Indole Alkaloids from Rauvolfia yunnanensis Tsiang. Molecules 2019, 24, 4574.

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