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Open AccessFeature PaperArticle

A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds

Green Chemistry Group, Chemistry Division, School of Science and Technology, University of Camerino, via S. Agostino 1, 62032 Camerino, Italy
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Academic Editor: Paola Vitale
Molecules 2019, 24(24), 4575; https://doi.org/10.3390/molecules24244575
Received: 21 November 2019 / Revised: 9 December 2019 / Accepted: 10 December 2019 / Published: 13 December 2019
Highly functionalized furans are the key scaffolds of many pharmaceuticals and bioactive natural products. Herein, we disclose a new fruitful synthesis of polyfunctionalized furans starting from β-nitroenones and α-functionalized ketones. The protocol involves two steps promoted by solid supported species, and it provides the title targets from satisfactory to very good overall yields and in an excellent diastereomeric ratios. View Full-Text
Keywords: furans; heterocycles; solid supported species; β-nitroenones; cyclization furans; heterocycles; solid supported species; β-nitroenones; cyclization
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MDPI and ACS Style

Chiurchiù, E.; Gabrielli, S.; Ballini, R.; Palmieri, A. A New Valuable Synthesis of Polyfunctionalized Furans Starting from β-Nitroenones and Active Methylene Compounds. Molecules 2019, 24, 4575.

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