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Molecules 2019, 24(2), 286;

Alcyonacea: A Potential Source for Production of Nitrogen-Containing Metabolites

Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO. Box 80207, Jeddah 21589, Saudi Arabia
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, PO Box 80260, Jeddah 21589, Saudi Arabia
Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Department of Chemistry, Faculty of Science, King Abdulaziz University, PO. Box 80203, Jeddah 21589, Saudi Arabia
Department of Biology, Faculty of Science, King Abdulaziz University, PO. Box 80203, Jeddah 21589, Saudi Arabia
Biology Department, College of Science, Princess Nourah bint Abdulrahman University, PO. Box 84428, Riyadh 11671, Saudi Arabia
Authors to whom correspondence should be addressed.
Received: 17 December 2018 / Revised: 9 January 2019 / Accepted: 9 January 2019 / Published: 14 January 2019
(This article belongs to the Section Natural Products Chemistry)
PDF [9056 KB, uploaded 15 January 2019]


Alcyonacea (soft corals and gorgonia) are well known for their production of a wide array of unprecedented architecture of bioactive metabolites. This diversity of compounds reported from Alcyonacea confirms its productivity as a source of drug leads and, consequently, indicates requirement of further chemo-biological investigation. This review can be considered a roadmap to investigate the Alcyonacea, particularly those produce nitrogen-containing metabolites. It covers the era from the beginning of marine nitrogen-containing terpenoids isolation from Alcyonacea up to December 2018. One hundred twenty-one compounds with nitrogenous moiety are published from fifteen genera. Their prominent biological activity is evident in their antiproliferative effect, which makes them interesting as potential leads for antitumor agents. For instance, eleutherobin and sarcodictyins are in preclinical or clinical stages.
Keywords: Alcyonacea; sesquiterpenes; diterpenes; antitumor; cytotoxicity Alcyonacea; sesquiterpenes; diterpenes; antitumor; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Alarif, W.M.; Abdel-Lateff, A.; Alorfi, H.S.; Alburae, N.A. Alcyonacea: A Potential Source for Production of Nitrogen-Containing Metabolites. Molecules 2019, 24, 286.

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