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Ferrocene-Based Compounds with Antimalaria/Anticancer Activity

Department of Chemistry, University of Fort Hare, Alice campus, Eastern Cape 5700, South Africa
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Author to whom correspondence should be addressed.
Academic Editors: Carlo Santini and Maura Pellei
Molecules 2019, 24(19), 3604; https://doi.org/10.3390/molecules24193604
Received: 11 July 2019 / Revised: 20 August 2019 / Accepted: 21 August 2019 / Published: 7 October 2019
(This article belongs to the Special Issue Metal-Based Drugs)
Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with other pharmaceutical scaffolds. This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity. View Full-Text
Keywords: organometallics; malaria; cancer; ferrocene compounds; ferroquine organometallics; malaria; cancer; ferrocene compounds; ferroquine
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MDPI and ACS Style

Peter, S.; Aderibigbe, B.A. Ferrocene-Based Compounds with Antimalaria/Anticancer Activity. Molecules 2019, 24, 3604.

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