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Six New Methyl Apiofuranosides from the Bark of Phellodendron chinense Schneid and Their Inhibitory Effects on Nitric Oxide Production

1,2,†, 1,2,†, 2, 2, 1,* and 1,2,*
1
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Francesco Epifano
Molecules 2019, 24(10), 1851; https://doi.org/10.3390/molecules24101851
Received: 14 April 2019 / Revised: 9 May 2019 / Accepted: 9 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
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Abstract

A chemical investigation on 70% EtOH extract from the bark of Phellodendron chinense Schneid (Rutaceae) led to six new methyl apiofuranosides (16), and ten known compounds (716). All these compounds were characterized by the basic analysis of the spectroscopic data including extensive 1D-, 2D-NMR (HSQC, HMBC), and high-resolution mass spectrometry, and the absolute configurations were determined by both empirical approaches and NOESY. Inhibitory effects of compounds 19 and 1116 on nitric oxide production were investigated in lipopolysaccharide (LPS)-mediated RAW 264.7 cells, as a result, most of these isolates inhibited nitric oxide (NO) release, and among them 9, 11, and 12 displayed the strongest inhibition on NO release at the concentration of 12.5 μM. View Full-Text
Keywords: Phellodendron chinense Schneid; methyl apiofuranoside; nitric oxide Phellodendron chinense Schneid; methyl apiofuranoside; nitric oxide
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Wang, P.-F.; Li, Y.-P.; Ding, L.-Q.; Cao, S.-J.; Wang, L.-N.; Qiu, F. Six New Methyl Apiofuranosides from the Bark of Phellodendron chinense Schneid and Their Inhibitory Effects on Nitric Oxide Production. Molecules 2019, 24, 1851.

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