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Molecules 2018, 23(6), 1397; https://doi.org/10.3390/molecules23061397

Hydrogen-Bonded Organic–Inorganic Hybrid Based on Hexachloroplatinate and Nitrogen Heterocyclic Cations: Their Synthesis, Characterization, Crystal Structures, and Antitumor Activities In Vitro

1
School of Pharmacy, Guangdong Medical University, Dongguan 523808, China
2
Guangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulation, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China
3
Department of Chemistry, Zhejiang University, Hangzhou 310027, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 May 2018 / Revised: 30 May 2018 / Accepted: 2 June 2018 / Published: 8 June 2018
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Abstract

Three new crystal structures containing [PtCl6]2−, pyridinium and benzimidazole groups have been prepared: [PtCl6]·(H-bzm)2·2(H2O) (1), [PtCl6]·(H-bipy)2·2(H2O) (2), [PtCl6]·(H-dimethyl-bipy)2·2(H2O) (3) [H-bzm: benzimidazole cation, H-bipy: 2,2′-bipyridine cation, H-dimethyl-bipy: 4,4′-bimethyl-2,2′-bipyridine cation]. All compounds have been fully characterized by elemental analyses, single-crystal X-ray analyses, IR spectra, TG analyses, and fluorescence studies. Single-crystal X-ray diffraction analysis suggests that the primary synthon contains +N–H···Cl, including ionic bonding and hydrogen bonding interactions. The dimensions are enhanced further by secondary O–H ∙∙Cl and N–H ∙∙O hydrogen bonding interactions between donor and acceptor atoms located at the periphery of these synthons. Moreover, coulombic attractions between the ions play an important role in reinforcing the structures of these complexes. In addition, antitumor activity against human lung adenocarcinoma cell line (A549) and human nasopharyngeal carcinoma cell line (CNE-2) was performed. These complexes all showed inhibition to the two cell lines, while complex 3 exhibited higher efficiency than complexes 12. View Full-Text
Keywords: organic–inorganic hybrid complexes; structure; hydrogen bonding; antitumor activities organic–inorganic hybrid complexes; structure; hydrogen bonding; antitumor activities
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Zhao, J.; Chen, F.; Han, Y.; Chen, H.; Luo, Z.; Tian, H.; Zhao, Y.; Ma, A.; Zhu, L. Hydrogen-Bonded Organic–Inorganic Hybrid Based on Hexachloroplatinate and Nitrogen Heterocyclic Cations: Their Synthesis, Characterization, Crystal Structures, and Antitumor Activities In Vitro. Molecules 2018, 23, 1397.

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