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Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum

State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
Authors to whom correspondence should be addressed.
Molecules 2018, 23(6), 1263;
Received: 10 April 2018 / Revised: 22 May 2018 / Accepted: 22 May 2018 / Published: 25 May 2018
(This article belongs to the Section Natural Products Chemistry)
PDF [1171 KB, uploaded 25 May 2018]


Sporulosol (1), a new ketal, together with four known compounds, has been isolated from the liquid fermentation cultures of a wetland-soil-derived fungus, Paraconiothyrium sporulosum. Its structure was elucidated primarily by NMR experiments, and was further confirmed by X-ray crystallography. Sporulosol was obtained as a racemic mixture and the resolved two enantiomers racemized immediately after chiral separation. Sporulosol appears to be the first ketal derived from a 6H-benzo[c]chromen-6-one and a benzofuranone unit. The compound showed modest cytotoxicity toward the human tumor cell line T24, with an IC50 value of 18.2 µM. View Full-Text
Keywords: Paraconiothyrium sporulosum; ketal; racemate; cytotoxicity Paraconiothyrium sporulosum; ketal; racemate; cytotoxicity

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Zhao, C.; Fu, P.; Zhang, Y.; Liu, X.; Ren, F.; Che, Y. Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum. Molecules 2018, 23, 1263.

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