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Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum

1
State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China
2
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
3
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(6), 1263; https://doi.org/10.3390/molecules23061263
Received: 10 April 2018 / Revised: 22 May 2018 / Accepted: 22 May 2018 / Published: 25 May 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Sporulosol (1), a new ketal, together with four known compounds, has been isolated from the liquid fermentation cultures of a wetland-soil-derived fungus, Paraconiothyrium sporulosum. Its structure was elucidated primarily by NMR experiments, and was further confirmed by X-ray crystallography. Sporulosol was obtained as a racemic mixture and the resolved two enantiomers racemized immediately after chiral separation. Sporulosol appears to be the first ketal derived from a 6H-benzo[c]chromen-6-one and a benzofuranone unit. The compound showed modest cytotoxicity toward the human tumor cell line T24, with an IC50 value of 18.2 µM. View Full-Text
Keywords: Paraconiothyrium sporulosum; ketal; racemate; cytotoxicity Paraconiothyrium sporulosum; ketal; racemate; cytotoxicity
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Zhao, C.; Fu, P.; Zhang, Y.; Liu, X.; Ren, F.; Che, Y. Sporulosol, a New Ketal from the Fungus Paraconiothyrium sporulosum. Molecules 2018, 23, 1263.

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