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Article

Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities

Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(5), 1198; https://doi.org/10.3390/molecules23051198
Received: 16 April 2018 / Revised: 7 May 2018 / Accepted: 14 May 2018 / Published: 17 May 2018
(This article belongs to the Collection Bioactive Compounds)
Seven pyrrole alkaloids, three of which are novel (phlebopines A–C (13)), were isolated from the fruiting bodies of the edible mushroom Phlebopus portentosus. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound 7 displayed remarkable neuroprotective effects against hydrogen peroxide (H2O2)-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells. View Full-Text
Keywords: Phlebopus portentosus; edible mushroom; pyrrole alkaloids; neuroprotection Phlebopus portentosus; edible mushroom; pyrrole alkaloids; neuroprotection
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MDPI and ACS Style

Sun, Z.; Hu, M.; Sun, Z.; Zhu, N.; Yang, J.; Ma, G.; Xu, X. Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities. Molecules 2018, 23, 1198. https://doi.org/10.3390/molecules23051198

AMA Style

Sun Z, Hu M, Sun Z, Zhu N, Yang J, Ma G, Xu X. Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities. Molecules. 2018; 23(5):1198. https://doi.org/10.3390/molecules23051198

Chicago/Turabian Style

Sun, Zhaocui, Meigeng Hu, Zhonghao Sun, Nailiang Zhu, Junshan Yang, Guoxu Ma, and Xudong Xu. 2018. "Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities" Molecules 23, no. 5: 1198. https://doi.org/10.3390/molecules23051198

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