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Molecules 2018, 23(5), 1008; https://doi.org/10.3390/molecules23051008

Nanotechnological Strategies for Protein Delivery

1
Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, UCM, 28040 Madrid, Spain
2
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Received: 9 April 2018 / Revised: 20 April 2018 / Accepted: 22 April 2018 / Published: 25 April 2018
(This article belongs to the Special Issue Targeted Drug Delivery and Nanocarriers)
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Abstract

The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target. Moreover, several proteins are unable to cross the cell membrane. All these facts strongly hinder their therapeutic effect. Nanomedicine has emerged as a powerful tool which can provide solutions to solve these limitations and improve the efficacy of treatments based on protein administration. This review discusses the advantages and limitations of different types of strategies employed for protein delivery, such as PEGylation, transport within liposomes or inorganic nanoparticles or their in situ encapsulation. View Full-Text
Keywords: protein delivery system; PEGylation; liposomes; nanoparticles; polymeric nanocapsules; protein therapy protein delivery system; PEGylation; liposomes; nanoparticles; polymeric nanocapsules; protein therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Villegas, M.R.; Baeza, A.; Vallet-Regí, M. Nanotechnological Strategies for Protein Delivery. Molecules 2018, 23, 1008.

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