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Function and Interactions of ERCC1-XPF in DNA Damage Response

Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
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Author to whom correspondence should be addressed.
Current address: College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA.
Academic Editor: Junji Iwahara
Molecules 2018, 23(12), 3205; https://doi.org/10.3390/molecules23123205
Received: 18 October 2018 / Revised: 27 November 2018 / Accepted: 1 December 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Protein-DNA Interactions: From Biophysics to Genomics)
Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1. View Full-Text
Keywords: ERCC1; XPF; DSB repair; ICL repair; NER; DNA damage response; Fanconi anemia ERCC1; XPF; DSB repair; ICL repair; NER; DNA damage response; Fanconi anemia
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MDPI and ACS Style

Faridounnia, M.; Folkers, G.E.; Boelens, R. Function and Interactions of ERCC1-XPF in DNA Damage Response. Molecules 2018, 23, 3205.

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