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Molecules 2018, 23(12), 3205; https://doi.org/10.3390/molecules23123205

Function and Interactions of ERCC1-XPF in DNA Damage Response

Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Current address: College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA.
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Author to whom correspondence should be addressed.
Academic Editor: Junji Iwahara
Received: 18 October 2018 / Revised: 27 November 2018 / Accepted: 1 December 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Protein-DNA Interactions: From Biophysics to Genomics)
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Abstract

Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1. View Full-Text
Keywords: ERCC1; XPF; DSB repair; ICL repair; NER; DNA damage response; Fanconi anemia ERCC1; XPF; DSB repair; ICL repair; NER; DNA damage response; Fanconi anemia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Faridounnia, M.; Folkers, G.E.; Boelens, R. Function and Interactions of ERCC1-XPF in DNA Damage Response. Molecules 2018, 23, 3205.

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