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Open AccessArticle

Synthesis and Characterization of a Bioartificial Polymeric System with Potential Antibacterial Activity: Chitosan-Polyvinyl Alcohol-Ampicillin

1
Grupo de Investigación en Ingeniería Biomédica, Vicerrectoría de Investigaciones, Universidad Manuela Beltrán, Avenida Circunvalar No. 60-00, Bogotá 1101, Colombia
2
Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Trida Tomase Bati 5678, 76001 Zlín, Czech Republic
3
Maestría en Educación, Universidad Antonio Nariño, Conciencia, Calle 22 sur No. 12D-81, Bogotá 1101, Colombia
*
Author to whom correspondence should be addressed.
Academic Editors: Sylvain Caillol and Guillaume Couture
Molecules 2018, 23(12), 3109; https://doi.org/10.3390/molecules23123109
Received: 31 August 2018 / Revised: 28 October 2018 / Accepted: 30 October 2018 / Published: 28 November 2018
(This article belongs to the Special Issue Natural Polymers and Biopolymers)
Bio-artificial polymeric systems are a new class of polymeric constituents based on blends of synthetic and natural polymers, designed with the purpose of producing new materials that exhibit enhanced properties with respect to the individual components. In this frame, a combination of polyvinyl alcohol (PVA) and chitosan, blended with a widely used antibiotic, sodium ampicillin, has been developed showing a moderate behavior in terms of antibacterial properties. Thus, aqueous solutions of PVA at 1 wt.% were mixed with acid solutions of chitosan at 1 wt.%, followed by adding ampicillin ranging from 0.3 to 1.0 wt.% related to the total amount of the polymers. The prepared bio-artificial polymeric system was characterized by FTIR, SEM, DSC, contact angle measurements, antibacterial activity against Staphylococcus aureus and Escherichia coli and antibiotic release studies. The statistical significance of the antibacterial activity was determined using a multifactorial analysis of variance with ρ < 0.05 (ANOVA). The characterization techniques did not show alterations in the ampicillin structure and the interactions with polymers were limited to intermolecular forces. Therefore, the antibiotic was efficiently released from the matrix and its antibacterial activity was preserved. The system disclosed moderate antibacterial activity against bacterial strains without adding a high antibiotic concentration. The findings of this study suggest that the system may be effective against healthcare-associated infections, a promising view in the design of novel antimicrobial biomaterials potentially suitable for tissue engineering applications. View Full-Text
Keywords: bio-artificial polymeric system; health-care associated infections; polyvinyl alcohol; chitosan; ampicillin bio-artificial polymeric system; health-care associated infections; polyvinyl alcohol; chitosan; ampicillin
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MDPI and ACS Style

Bernal-Ballen, A.; Lopez-Garcia, J.; Merchan-Merchan, M.-A.; Lehocky, M. Synthesis and Characterization of a Bioartificial Polymeric System with Potential Antibacterial Activity: Chitosan-Polyvinyl Alcohol-Ampicillin. Molecules 2018, 23, 3109.

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