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Open AccessArticle

Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD

by Tianqiao Yong 1,2,*,†, Dan Li 1,2,3,†, Muxia Li 1,2,3,†, Danling Liang 1,2,3, Xue Diao 1,2, Chenling Deng 1,2, Shaodan Chen 1,2, Yizhen Xie 1,2,*, Diling Chen 1,3 and Dan Zuo 4
1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application and Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
2
R & D Department, Guangdong Yuewei Edible Fungi Technology Co., Guangzhou 510663, China
3
College of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, China
4
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(10), 2671; https://doi.org/10.3390/molecules23102671
Received: 30 August 2018 / Revised: 25 September 2018 / Accepted: 12 October 2018 / Published: 17 October 2018
(This article belongs to the Special Issue QSAR and QSPR: Recent Developments and Applications)
Conventionally, benzophenone-type molecules are beneficial for alleviating the UV exposure of humans. More importantly, various compounds with this skeleton have demonstrated various biological activities. In this paper, we report the anti-hyperuricemic effect of the benzophenone compound 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (HMS). Preliminarily, its molecular docking score and xanthine oxidase (XOD) inhibition suggested a good anti-hyperuricemic effect. Then, its anti-hyperuricemic effect, primary mechanisms and general toxicity were examined on a hyperuricemic mouse model which was established using potassium oxonate and hypoxanthine together. HMS demonstrated a remarkable anti- hyperuricemic effect which was near to that of the control drugs, showing promising perspective. General toxicity was assessed and it showed no negative effects on body weight growth and kidney function. Moreover, anti-inflammatory action was observed for HMS via spleen and thymus changes. Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9). View Full-Text
Keywords: 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid; hyperuricemia; xanthine oxidase; organic anion transporter 1; toxicity 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid; hyperuricemia; xanthine oxidase; organic anion transporter 1; toxicity
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MDPI and ACS Style

Yong, T.; Li, D.; Li, M.; Liang, D.; Diao, X.; Deng, C.; Chen, S.; Xie, Y.; Chen, D.; Zuo, D. Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD. Molecules 2018, 23, 2671.

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