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Article

Chromobacterium violaceum and Pseudomonas aeruginosa PAO1: Models for Evaluating Anti-Quorum Sensing Activity of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-ol

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Laboratory of Bioressources: Integrative Biology & Recovery, High Institute of Biotechnology-University of Monastir, Monastir 5000, Tunisia
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Department of Biology, College of Science, Hail, P.O. 2440, University of Ha’il, Hail 2440, Saudi Arabia
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Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, University of Monastir, Monastir 5000, Tunisia
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University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis 1007, Tunisia
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Ula Ali Kocman Vocational School, Mugla SitkiKocman University, Mugla 48147, Turkey
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Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno 84084, Italy
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Laboratory of Genetics, Biodiversity and Valorisation of Bioresources, High Institute of Biotechnology-University of Monastir, Monastir 5000, Tunisia
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Department of Biochemistry, Faculty of Science, King Abdul Aziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(10), 2672; https://doi.org/10.3390/molecules23102672
Received: 30 July 2018 / Revised: 8 October 2018 / Accepted: 11 October 2018 / Published: 17 October 2018
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
The problem of antibiotic resistance among pathogens encourages searching for novel active molecules. The aim of the research was to assay the anti-quorum sensing (anti-QS) and antibiofilm potential of Melaleuca alternifolia essential oil and its main constituent, terpinen-4-ol, to prevent the infections due to methicillin-resistant Staphylococcus aureus strains as an alternate to antibiotics. The tea tree oil (TTO) was evaluated for its potential in inhibiting QS-dependent phenomena such as violacein production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1, and biofilm formation in MRSA strains on glass. The results showed that terpinen-4-ol was able to inhibit MRSA strain biofilm formation on the glass strips by 73.70%. TTO inhibited the violacein production at a mean inhibitory concentration (MIC) value of 0.048 mg/mL by 69.3%. At 100 µg/mL TTO and terpinen-4-ol exhibited inhibition in swarming motility of PAO1 by 33.33% and 25%, respectively. TTO revealed anti-QS and anti-biofilm activities at very low concentrations, but it could be further investigated for new molecules useful for the treatment of MRSA infections. View Full-Text
Keywords: TTO; terpinen-4-ol; MRSA; biofilm; anti-quorum sensing; violacein; Chromobacterium violaceum; Pseudomonas aeruginosa TTO; terpinen-4-ol; MRSA; biofilm; anti-quorum sensing; violacein; Chromobacterium violaceum; Pseudomonas aeruginosa
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MDPI and ACS Style

Noumi, E.; Merghni, A.; M. Alreshidi, M.; Haddad, O.; Akmadar, G.; De Martino, L.; Mastouri, M.; Ceylan, O.; Snoussi, M.; Al-sieni, A.; De Feo, V. Chromobacterium violaceum and Pseudomonas aeruginosa PAO1: Models for Evaluating Anti-Quorum Sensing Activity of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-ol. Molecules 2018, 23, 2672. https://doi.org/10.3390/molecules23102672

AMA Style

Noumi E, Merghni A, M. Alreshidi M, Haddad O, Akmadar G, De Martino L, Mastouri M, Ceylan O, Snoussi M, Al-sieni A, De Feo V. Chromobacterium violaceum and Pseudomonas aeruginosa PAO1: Models for Evaluating Anti-Quorum Sensing Activity of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-ol. Molecules. 2018; 23(10):2672. https://doi.org/10.3390/molecules23102672

Chicago/Turabian Style

Noumi, Emira; Merghni, Abderrahmen; M. Alreshidi, Mousa; Haddad, Ons; Akmadar, Gültekin; De Martino, Laura; Mastouri, Maha; Ceylan, Ozgur; Snoussi, Mejdi; Al-sieni, Abdulbasit; De Feo, Vincenzo. 2018. "Chromobacterium violaceum and Pseudomonas aeruginosa PAO1: Models for Evaluating Anti-Quorum Sensing Activity of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-ol" Molecules 23, no. 10: 2672. https://doi.org/10.3390/molecules23102672

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