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Molecules 2017, 22(8), 1263;

Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts

Department of Chemistry, 401 College Ave., Ashland University, Ashland, OH 44805, USA
Department of Chemistry, University of Akron, Akron, OH 44325, USA
Author to whom correspondence should be addressed.
Academic Editor: Sylvain Roland
Received: 1 July 2017 / Revised: 21 July 2017 / Accepted: 22 July 2017 / Published: 27 July 2017
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Because of their great structural diversity and multitude of chemical properties, N-heterocyclic carbenes (NHCs) have been utilized in a variety of capacities. Most recently, NHCs have been utilized as carrier molecules for many transition metals in medicinal chemistry. Specifically, Ag(I)-NHCs have been investigated as potent antibacterial agents and chemotherapeutics and have shown great efficacy in both in vitro and in vivo studies. Ag(I)-NHC compounds have been shown to be effective against a wide range of both Gram-positive and Gram-negative bacterial strains. Many compounds have also shown great efficacy as antitumor agents demonstrating comparable or better antitumor activity than standard chemotherapeutics such as cisplatin and 5-fluorouracil. While these compounds have shown great promise, clinical use has remained an unattained goal. Current research has been focused upon synthesis of novel Ag(I)-NHC compounds and further investigations of their antibacterial and antitumor activity. This review will focus on recent advances of Ag(I)-NHCs in medicinal applications. View Full-Text
Keywords: silver; NHC; imidazolium salt; antibacterial; antitumor; chemotherapeutic silver; NHC; imidazolium salt; antibacterial; antitumor; chemotherapeutic

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Johnson, N.A.; Southerland, M.R.; Youngs, W.J. Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts. Molecules 2017, 22, 1263.

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