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Molecules 2017, 22(7), 1168;

Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum

Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry,Jiangsu Second Normal University, Nanjing 210003, China
School of Biomedicine, Beijing City University, Beijing 100083, China
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 14 June 2017 / Revised: 8 July 2017 / Accepted: 8 July 2017 / Published: 12 July 2017
(This article belongs to the Collection Bioactive Compounds)
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Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh2(OCOCF3)4] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7. View Full-Text
Keywords: Tolypocladium inflatum; structure elucidation; biological activities Tolypocladium inflatum; structure elucidation; biological activities

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Lin, J.; Niu, S.; Ding, Z.; Wang, R.; Dai, Q.; Wei, W.; Luo, R.; Liu, L. Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum. Molecules 2017, 22, 1168.

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