Next Article in Journal
Microwave-Assisted Facile Synthesis, Anticancer Evaluation and Docking Study of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives
Next Article in Special Issue
Efficiency of Dinucleosides as the Backbone to Pre-Organize Multi-Porphyrins and Enhance Their Stability as Sandwich Type Complexes with DABCO
Previous Article in Journal
Response Surface Optimized Infrared-Assisted Extraction and UHPLC Determination of Flavonoid Types from Flos Sophorae
Previous Article in Special Issue
Molecular Orientation of a Terbium(III)-Phthalocyaninato Double-Decker Complex for Effective Suppression of Quantum Tunneling of the Magnetization
Open AccessReview

Coumarin–Tetrapyrrolic Macrocycle Conjugates: Synthesis and Applications

Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal
Author to whom correspondence should be addressed.
Molecules 2017, 22(6), 994;
Received: 16 May 2017 / Revised: 9 June 2017 / Accepted: 12 June 2017 / Published: 15 June 2017


This review covers the synthesis of coumarin–porphyrin, coumarin–phthalocyanine and coumarin–corrole conjugates and their potential applications. While coumarin–phthalocyanine conjugates were obtained almost exclusively by tetramerization of coumarin-functionalized phthalonitriles, coumarin–porphyrin and coumarin–corrole conjugates were prepared by complementary approaches: (a) direct synthesis of the tetrapyrrolic macrocycle using formylcoumarins and pyrrole or (b) by functionalization of the tetrapyrrolic macrocycle. In the last approach a range of reaction types were used, namely 1,3-dipolar cycloadditions, hetero-Diels–Alder, Sonogashira, alkylation or acylation reactions. This is clearly a more versatile approach, leading to a larger diversity of conjugates and allowing the access to conjugates bearing one to up to 16 coumarin units. View Full-Text
Keywords: coumarins; porphyrins; phthalocyanines; corroles coumarins; porphyrins; phthalocyanines; corroles

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Cerqueira, A.F.R.; Almodôvar, V.A.S.; Neves, M.G.P.M.S.; Tomé, A.C. Coumarin–Tetrapyrrolic Macrocycle Conjugates: Synthesis and Applications. Molecules 2017, 22, 994.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top