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Molecules 2017, 22(5), 763;

Synthesis and Evaluation of Essential Oil-Derived β-Methoxyacrylate Derivatives as High Potential Fungicides

College of Science, Huazhong Agricultural University, Wuhan 430070, China
Author to whom correspondence should be addressed.
Academic Editors: Daniela Barlocco and Fiorella Meneghetti
Received: 31 March 2017 / Revised: 5 May 2017 / Accepted: 5 May 2017 / Published: 8 May 2017
(This article belongs to the Special Issue Frontiers in Antimicrobial Drug Discovery and Design)
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Essential oils (EOs) are plant-derived aroma compounds with a wide range of biological activity, but their actions are slow, and they are typically unstable to light or heat, difficult to extract and so on. To find highly potential fungicides derived from natural EOs, a series of essential oil-based β-methoxyacrylate derivatives have been designed and synthesized. The target compounds have been screened for their potential fungicidal activity against eleven species of plant pathogen fungi, including Alternaria alternata, Phomopsis adianticola, Pestalotiopsis theae, Sclerotinia sclerotiorum, etc. Compared with intermediates I, the parent essential oils and azoxystrobin, almost all of essential oil-based β-methoxyacrylate derivatives exhibited significantly better fungicidal activity. Further investigation revealed that some compounds showed remarkable inhibitory activities against Pestalotiopsis theae, Phomopsis adianticola, Sclerotinia sclerotiorum and Magnapothe grisea at different concentrations in contrast to the commercial product azoxystrobin. Compound II-8 exhibited particularly significant fungicidal activity. View Full-Text
Keywords: essential oils; β-methoxyacrylate; hybrids; synthesis; fungicidal activity essential oils; β-methoxyacrylate; hybrids; synthesis; fungicidal activity

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Su, H.; Wang, W.; Bao, L.; Wang, S.; Cao, X. Synthesis and Evaluation of Essential Oil-Derived β-Methoxyacrylate Derivatives as High Potential Fungicides. Molecules 2017, 22, 763.

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