Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes
AbstractThe quest for alternative drugs with respect to the well-known cis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes, evaluated using liposomes as bio-membrane mimetic model systems, seems to be relevant. The biological activity of these compounds, particularly those based on yttrium, already effective at low concentrations on both cancer cell lines, should be taken into account with regard to new therapeutic approaches in anticancer therapy. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 257 KB)
Share & Cite This Article
Caporale, A.; Palma, G.; Mariconda, A.; Del Vecchio, V.; Iacopetta, D.; Parisi, O.I.; Sinicropi, M.S.; Puoci, F.; Arra, C.; Longo, P.; Saturnino, C. Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes. Molecules 2017, 22, 526.
Caporale A, Palma G, Mariconda A, Del Vecchio V, Iacopetta D, Parisi OI, Sinicropi MS, Puoci F, Arra C, Longo P, Saturnino C. Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes. Molecules. 2017; 22(4):526.Chicago/Turabian Style
Caporale, Angelamaria; Palma, Giuseppe; Mariconda, Annaluisa; Del Vecchio, Vitale; Iacopetta, Domenico; Parisi, Ortensia I.; Sinicropi, Maria S.; Puoci, Francesco; Arra, Claudio; Longo, Pasquale; Saturnino, Carmela. 2017. "Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes." Molecules 22, no. 4: 526.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.