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Molecules 2017, 22(2), 200;

Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing

School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia
Author to whom correspondence should be addressed.
Academic Editor: Zhen Cheng
Received: 28 November 2016 / Revised: 13 January 2017 / Accepted: 16 January 2017 / Published: 25 January 2017
(This article belongs to the Special Issue Molecular Imaging Probes)
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Small-molecule fluorescent probes play a myriad of important roles in chemical sensing. Many such systems incorporating a receptor component designed to recognise and bind a specific analyte, and a reporter or transducer component which signals the binding event with a change in fluorescence output have been developed. Fluorescent probes use a variety of mechanisms to transmit the binding event to the reporter unit, including photoinduced electron transfer (PET), charge transfer (CT), Förster resonance energy transfer (FRET), excimer formation, and aggregation induced emission (AIE) or aggregation caused quenching (ACQ). These systems respond to a wide array of potential analytes including protons, metal cations, anions, carbohydrates, and other biomolecules. This review surveys important new fluorescence-based probes for these and other analytes that have been reported over the past five years, focusing on the most widely exploited macrocyclic recognition components, those based on cyclam, calixarenes, cyclodextrins and crown ethers; other macrocyclic and non-macrocyclic receptors are also discussed. View Full-Text
Keywords: chemosensor; fluorescence sensing; fluoroionophore; spectroscopy; molecular probes chemosensor; fluorescence sensing; fluoroionophore; spectroscopy; molecular probes

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wong, J.K.-H.; Todd, M.H.; Rutledge, P.J. Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing. Molecules 2017, 22, 200.

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